{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:42:37Z","timestamp":1761662557174},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T00:00:00Z","timestamp":1203033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study aimed to establish the feasibility and cost-effectiveness of rapid molecular screening for hospital-acquired meticillin-resistant Staphylococcus aureus (MRSA) in surgical patients within a teaching hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 2006, nasal swabs were obtained before surgery from all patients undergoing elective and emergency procedures, and screened for MRSA using a rapid molecular technique. MRSA-positive patients were started on suppression therapy of mupirocin nasal ointment (2 per cent) and undiluted chlorhexidine gluconate bodywash.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 18 810 samples were processed, of which 850 (4\u00b75 per cent) were MRSA positive. In comparison to the annual mean for the preceding 6 years, MRSA bacteraemia fell by 38\u00b75 per cent (P &amp;lt; 0\u00b7001), and MRSA wound isolates fell by 12\u00b77 per cent (P = 0\u00b7031). The reduction in MRSA bacteraemia and wound infection was equivalent to a saving of 3\u00b778 beds per year (\u00a3276 220), compared with the annual mean for the preceding 6 years. The cost of screening was \u00a3302 500, making a net loss of \u00a326 280. Compared with 2005, however, there was a net saving of \u00a3545 486.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Rapid MRSA screening of all surgical admissions resulted in a significant reduction in staphylococcal bacteraemia during the screening period, although a causal link cannot be established.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6013","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T12:47:08Z","timestamp":1196167628000},"page":"381-386","source":"Crossref","is-referenced-by-count":41,"title":["Impact of rapid molecular screening for meticillin-resistant <i>Staphylococcus aureus<\/i> in surgical wards"],"prefix":"10.1093","volume":"95","author":[{"given":"M R S","family":"Keshtgar","sequence":"first","affiliation":[{"name":"Department of Surgery, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Surgery, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Coen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Carder","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Macrae","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Jeanes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Folan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Wren","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P R","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Windeyer Institute of Medical Sciences, University College London Hospitals Foundation Trust , 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