{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:36:50Z","timestamp":1758476210991,"version":"3.34.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"University of Berne and by the Chiron Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients taking immunosuppressants after transplantation may require intestinal surgery. Mycophenolate mofetil (MMF) has been found to impair the healing of colonic anastomoses in rats. This study examined whether insulin-like growth factor (IGF) I prevents MMF impairment of anastomotic healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty-three rats were divided into three groups (MMF, MMF\/IGF and control). Animals underwent a sigmoid colon anastomosis with a 6\/0 suture, and were killed on days 2, 4 and 6 after surgery. Investigations included bursting pressure measurement, morphometric analysis, and assessment of mucosal proliferation by 5-bromo-2\u2032-deoxyuridine and Ki67 immunohistochemistry of the anastomoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The leak rate was three of 21, one of 20 and two of 20 in the MMF, MMF\/IGF-I and control groups respectively. Anastomotic bursting pressures were significantly lower in the MMF group than in the control group on days 2 and 4, but there was no significant difference by day 6. Values in the MMF\/IGF-I and control groups were similar. Colonic crypt depth was significantly reduced in MMF-treated animals on days 2 and 4, but this impairment was attenuated by IGF-I on day 4. Similarly, IGF-I reduced the negative impact of MMF on mucosal proliferation on days 2 and 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exogenous IGF-I improves some aspects of MMF-impaired anastomotic healing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.6053","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T16:47:52Z","timestamp":1208364472000},"page":"793-798","source":"Crossref","is-referenced-by-count":14,"title":["Insulin-like growth factor I improves aspects of mycophenolate mofetil-impaired anastomotic healing in an experimental model"],"prefix":"10.1093","volume":"95","author":[{"given":"R A","family":"Inglin","sequence":"first","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, Inselspital, University of Berne, CH-3010 Berne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of 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