{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:50:31Z","timestamp":1791888631842,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T00:00:00Z","timestamp":1203033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sepsis is a feared complication in patients with an absent or dysfunctioning spleen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A literature search was undertaken to identify recommendations for vaccination in asplenic or hyposplenic adults, and published data regarding the effectiveness of the vaccines in reducing the incidence of infections, and vaccine failures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Various committees and organizations recommend that the pneumococcal, meningococcal and Haemophilus influenza vaccine, plus booster doses, should be administered to patients with an absent or dysfunctional spleen. However, adherence to such recommendations varies. Furthermore, vaccine failures still occur in a subset of properly immunized individuals. Immunocompromised individuals, in particular, have a greater risk of inadequate antibody response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Immunization is partially responsible for the observed reduction in sepsis after splenectomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6106","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T16:16:47Z","timestamp":1203092207000},"page":"273-280","source":"Crossref","is-referenced-by-count":54,"title":["Vaccination of asplenic or hyposplenic adults"],"prefix":"10.1093","volume":"95","author":[{"given":"E G","family":"Mourtzoukou","sequence":"first","affiliation":[{"name":"Alfa Institute of Biomedical Sciences, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Pappas","sequence":"additional","affiliation":[{"name":"Institute of Continuing Medical Education of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Peppas","sequence":"additional","affiliation":[{"name":"Alfa Institute of Biomedical Sciences, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Falagas","sequence":"additional","affiliation":[{"name":"Alfa Institute of Biomedical Sciences, Athens, Greece"},{"name":"Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,2,15]]},"reference":[{"key":"2021070907410026300_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/bjs.1800780305","article-title":"Regeneration of the spleen and splenic autotransplantation","volume":"78","author":"Holdsworth","year":"1991","journal-title":"Br J Surg"},{"key":"2021070907410026300_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0891-5520(05)70322-6","article-title":"Overwhelming postsplenectomy infection","volume":"10","author":"Lynch","year":"1996","journal-title":"Infect Dis Clin North Am"},{"key":"2021070907410026300_bib3","first-page":"33N","article-title":"Infection associated with asplenia: risks, mechanisms, and prevention","volume":"88","author":"Styrt","year":"1990","journal-title":"Am J Med"},{"key":"2021070907410026300_bib4","first-page":"1","article-title":"General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"55","author":"Kroger","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"2021070907410026300_bib5","volume-title":"Recommended Adult Immunization Schedule\u2014United States, October 2007\u2013September 2008","author":"Centers for Disease Control and Prevention"},{"key":"2021070907410026300_bib6","article-title":"Surgical Treatment of Disease and Injuries of the Spleen","author":"National Guideline Clearinghouse","year":"2004","journal-title":"Society for Surgery of the Alimentary Tract"},{"key":"2021070907410026300_bib7","volume-title":"Post-splenectomy Vaccine Prophylaxis","author":"Department of Surgical Education, Orlando Regional Medical Center"},{"key":"2021070907410026300_bib8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.7861\/clinmedicine.2-5-440","article-title":"British Committee for Standards in Haematology. 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