{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:56:16Z","timestamp":1792670176205,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T00:00:00Z","timestamp":1213747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Early detection of colorectal cancer could reduce cancer-specific mortality. The aim of this trial was to evaluate the effect of faecal occult blood test (FOBT) screening on colorectal cancer mortality in a Swedish population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All 68 308 citizens in G\u00f6teborg born between 1918 and 1931 were randomized to a screening or a control group at the age of 60\u201364 years. All were screened two to three times with rehydrated Hemoccult-II\u00ae. Compliance was 70\u00b70 per cent (23 916 individuals). Those with a positive test result were offered sigmoidoscopy and a double-contrast enema. The primary endpoint was death from colorectal cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After a mean of 9 years from the last screening, there was a significant reduction in colorectal cancer mortality in the screening group compared with the control group. The overall risk ratio of death from colorectal cancer was 0\u00b784 (95 per cent confidence interval 0\u00b771 to 0\u00b799). The groups did not differ in incidence of colorectal cancer or in overall mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>FOBT screening significantly reduces colorectal cancer mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6136","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T15:33:39Z","timestamp":1213803219000},"page":"1029-1036","source":"Crossref","is-referenced-by-count":246,"title":["Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer"],"prefix":"10.1093","volume":"95","author":[{"given":"E","family":"Lindholm","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Surgical Sciences, G\u00f6teborg University, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Brevinge","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Surgical Sciences, G\u00f6teborg University, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Haglind","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Surgical Sciences, G\u00f6teborg University, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,6,18]]},"reference":[{"key":"2021070907425332200_bib1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJM199305133281901","article-title":"Reducing mortality from colorectal cancer by screening for fecal occult blood. 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