{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:27:50Z","timestamp":1792794470264,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T00:00:00Z","timestamp":1218153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pseudomyxoma peritonei (PMP) is characterized by progressive intraperitoneal accumulation of mucous and mucinous implants, usually derived from a ruptured, possibly malignant mucinous neoplasm of the appendix. Treatment based on complete cytoreductive surgery (CCRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is gaining support. The aim of this study was to identify pre- and perioperative factors of prognostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 105 patients (with no residual tumours exceeding 2 mm) were treated with CCRS plus HIPEC based on oxaliplatin. Clinical, radiological, pathological factors and blood markers were analysed to determine their prognostic value for survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mortality (7\u00b76 per cent) and morbidity (67\u00b76 per cent) were significantly correlated with peritoneal index, pathological grade and blood CA19\u00b79 level. The median follow-up was 48 months. Seven patients died after hospital discharge. Overall and disease-free 5-year survival rates were 80\u00b70 and 68\u00b75 per cent respectively. The Cox model identified only two significant factors impacting on disease-free survival: CA19\u00b79 level and pathological grade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CCRS is the most effective treatment for PMP, and adding HIPEC prolongs long-term survival. Further strategies should focus on improving postoperative outcome in extended PMP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.6235","type":"journal-article","created":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T05:23:15Z","timestamp":1218172995000},"page":"1164-1171","source":"Crossref","is-referenced-by-count":110,"title":["Peritoneal pseudomyxoma: results of a systematic policy of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1093","volume":"95","author":[{"given":"D","family":"Elias","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Honor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Ciuchend\u00e9a","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Billard","sequence":"additional","affiliation":[{"name":"Service of Anesthesiology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Raynard","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Lo Dico","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Dromain","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Duvillard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Go\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Gustave Roussy Institute, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,8,8]]},"reference":[{"key":"2021070911092002100_bib1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0002-9440(10)64211-3","article-title":"Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells","volume":"161","author":"O'Connel","year":"2002","journal-title":"Am J Pathol"},{"key":"2021070911092002100_bib2","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/00000478-199512000-00006","article-title":"Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis and relationship to \u201cpseudomyxoma peritonei\u201d","volume":"19","author":"Ronnett","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"2021070911092002100_bib3","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0002-9440(10)65442-9","article-title":"Molecular genetic evidence supporting the clonality and appendiceal origin of pseudomyxoma peritonei in women","volume":"154","author":"Szych","year":"1999","journal-title":"Am J Pathol"},{"key":"2021070911092002100_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/1097-0142(20010701)92:1<85::AID-CNCR1295>3.0.CO;2-R","article-title":"Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosis","volume":"92","author":"Ronnett","year":"2001","journal-title":"Cancer"},{"key":"2021070911092002100_bib5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/01.sla.0000152015.76731.1f","article-title":"Long-term survival following treatment of pseudomyxoma peritonei: an analysis of surgical therapy","volume":"241","author":"Miner","year":"2005","journal-title":"Ann Surg"},{"key":"2021070911092002100_bib6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1055-3207(03)00026-7","article-title":"The etiology, clinical presentation, and management of pseudomyxoma peritonei","volume":"12","author":"Moran","year":"2003","journal-title":"Sur Oncol Clin N Am"},{"key":"2021070911092002100_bib7","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1245\/s10434-006-9182-x","article-title":"A systematic review on the efficacy of cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei","volume":"14","author":"Yan","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"2021070911092002100_bib8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10434-999-0727-7","article-title":"Results of treatment of 385 patients with peritoneal surface spread of appendiceal malignancy","volume":"6","author":"Sugarbaker","year":"1999","journal-title":"Ann Surg Oncol"},{"key":"2021070911092002100_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1470-2045(05)70539-8","article-title":"New standard of care for appendiceal epithelial neoplasms and pseudomyxoma syndrome?","volume":"7","author":"Sugarbaker","year":"2006","journal-title":"Lancet Oncol"},{"key":"2021070911092002100_bib10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1046\/j.1365-2168.2001.01701.x","article-title":"Extensive surgical cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in patients with pseudomyxoma peritonei","volume":"88","author":"Witkamp","year":"2001","journal-title":"Br J Surg"},{"key":"2021070911092002100_bib11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/01.sla.0000231705.40081.1a","article-title":"Survival analysis of pseudomyxoma peritonei patients treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"245","author":"Smeenk","year":"2007","journal-title":"Ann Surg"},{"key":"2021070911092002100_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10350-006-0741-9","article-title":"Early results of surgery in 123 patients with pseudomyxoma peritonei from a perforated appendiceal neoplasm","volume":"50","author":"Murphy","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"2021070911092002100_bib13","first-page":"3380","article-title":"Direct diffusion of cis-Diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy","volume":"48","author":"Los","year":"1989","journal-title":"Cancer Res"},{"key":"2021070911092002100_bib14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0959-8049(97)00370-5","article-title":"Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: phamacokinetics and cisplatin-DNA adducts formation in patients","volume":"34","author":"van de Vaart","year":"1998","journal-title":"Eur J Cancer"},{"key":"2021070911092002100_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1098-2388(199804\/05)14:3<254::AID-SSU10>3.0.CO;2-U","article-title":"Intraperitoneal chemotherapy and cytoreductive surgery for the prevention and treatment of peritoneal carcinomatosis and sarcomatosis","volume":"14","author":"Sugarbaker","year":"1998","journal-title":"Semin Surg Oncol"},{"key":"2021070911092002100_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00000658-199501000-00004","article-title":"Peritonectomy procedures","volume":"221","author":"Sugarbaker","year":"1995","journal-title":"Ann Surg"},{"key":"2021070911092002100_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications. A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"2021070911092002100_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1245\/ASO.2004.07.002","article-title":"Peritonectomy and intraperitoneal hyperthermic perfusion (IPHP): a strategy that has confirmed its efficacy in patients with pseudomyxoma peritonei","volume":"11","author":"Deraco","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"2021070911092002100_bib19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/00000658-199402000-00002","article-title":"Pseudomyxoma peritonei. Long-term patient survival with an aggressive regional approach","volume":"219","author":"Gough","year":"1994","journal-title":"Ann Surg"},{"key":"2021070911092002100_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/01.sla.0000133183.15705.71","article-title":"Incomplete cytoreduction in 174 patients with peritoneal carcinomatosis from appendiceal malignancy","volume":"240","author":"Glehen","year":"2004","journal-title":"Ann Surg"},{"key":"2021070911092002100_bib21","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s10434-006-9708-2","article-title":"Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy","volume":"13","author":"Stewart","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"2021070911092002100_bib22","first-page":"1840","article-title":"Treatment of implanted peritoneal cancer in rats with continuous hyperthermic peritoneal perfusion in combination with an anticancer drug","volume":"44","author":"Koga","year":"1984","journal-title":"Cancer Res"},{"key":"2021070911092002100_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1471-2407-6-162","article-title":"Histological response of peritoneal carcinomatosis after hyperthermic intraperitoneal chemoperfusion (HIPEC) in experimental investigations","volume":"6","author":"Pelz","year":"2006","journal-title":"BMC Cancer"},{"key":"2021070911092002100_bib24","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0277-5379(91)90389-U","article-title":"Optimisation of intraperitoneal cisplatin therapy with regional hyperthermia in rats","volume":"27","author":"Los","year":"1991","journal-title":"Eur J Cancer"},{"key":"2021070911092002100_bib25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ejso.2005.08.009","article-title":"Toxicity and mortality of cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei\u2014a report of 103 procedures","volume":"32","author":"Smeenk","year":"2006","journal-title":"Eur J Surg Oncol"},{"key":"2021070911092002100_bib26","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/bjs.5427","article-title":"Cytoreductive surgery and peritoneal intraperitoneal chemotherapy for pseudomyxoma peritonei from appendiceal mucinous neoplasms","volume":"93","author":"Yan","year":"2006","journal-title":"Br J Surg"},{"key":"2021070911092002100_bib27","first-page":"A181","article-title":"Effet de la chimioth\u00e9rapie syst\u00e9mique sur la maladie g\u00e9latineuse du p\u00e9ritoine","volume":"31","author":"Rahmi","year":"2007","journal-title":"Gastroent\u00e9rol Clin Biol"},{"key":"2021070911092002100_bib28","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1007\/s10350-005-0045-5","article-title":"Cytoreductive surgery with intraperitoneal chemohyperthermia for the treatment of pseudomyxoma peritonei: a prospective study","volume":"48","author":"Loungnarath","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"2021070911092002100_bib29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/modpathol.3880276","article-title":"Histopathological analysis in 46 patients with pseudomyxoma peritonei syndrome: failure versus success with a second-look operation","volume":"14","author":"Yan","year":"2001","journal-title":"Med Pathol"},{"key":"2021070911092002100_bib30","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0399-8320(06)73512-6","article-title":"Peritoneal carcinomatosis of colorectal origin. Long-term results of intraperitoneal chemohyperthermia with oxaliplatin following complete cytoreductive surgery","volume":"30","author":"Elias","year":"2006","journal-title":"Gastroenterol Clin Biol"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.6235","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/95\/9\/1164\/36709817\/bjs6235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/95\/9\/1164\/36709817\/bjs6235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T16:34:46Z","timestamp":1625848486000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/95\/9\/1164\/6142659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,8]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2008,8,8]]},"published-print":{"date-parts":[[2008,8,8]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.6235","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,9]]},"published":{"date-parts":[[2008,8,8]]}}}