{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:22:43Z","timestamp":1768699363695,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The clinical significance of false-negative axillary sentinel lymph node (SLN) biopsy has yet to be established. The aim of this study was to assess the axillary recurrence rate and false-negative rate, to identify prognostic factors and to monitor survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective registry of sentinel lymph node biopsy (SLNB) procedures performed between 1998 and 2004 was analysed. All nodes retrieved were examined by haematoxylin and eosin and immunohistochemical staining. Further surgical treatment was performed only for positive SLNs. Adjuvant treatment was given according to Dutch guidelines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 592 patients, 392 had a negative SLNB. After a median follow-up of 65 months, 11 patients developed axillary recurrence (2\u00b78 per cent). Ten of these patients were primarily treated by simple mastectomy and therefore had no external-beam radiation therapy; no further prognostic factors could be identified. The false-negative rate was 6\u00b79 per cent. The median time from SLNB to detection of the axillary recurrence was 27 months. The median follow-up after recurrence was 35 months, and one patient developed systemic disease. Pathology revision revealed two previously undetected micrometastases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Axillary recurrence and false-negative rates after SLNB increase with longer follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6348","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T15:45:33Z","timestamp":1223653533000},"page":"1352-1355","source":"Crossref","is-referenced-by-count":19,"title":["False-negative sentinel lymph node biopsy"],"prefix":"10.1093","volume":"95","author":[{"given":"B J","family":"van Wely","sequence":"first","affiliation":[{"name":"Department of Surgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Smidt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sint Fransiscus Hospital, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"de Kievit","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A P","family":"Wauters","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J A","family":"Strobbe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"2021070911075810500_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/cncr.21568","article-title":"Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a metaanalysis","volume":"106","author":"Kim","year":"2006","journal-title":"Cancer"},{"key":"2021070911075810500_bib2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/jsre.1999.5629","article-title":"Meta-analysis of sentinel lymph node biopsy in breast cancer","volume":"84","author":"Miltenburg","year":"1999","journal-title":"J Surg Res"},{"key":"2021070911075810500_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1245\/ASO.2003.07.026","article-title":"Patterns of recurrence after sentinel lymph node biopsy for breast cancer","volume":"10","author":"Badgwell","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"2021070911075810500_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/00015458.2007.11680056","article-title":"Incidence of axillary recurrence in 344 sentinel node negative breast cancer patients after intermediate follow-up. 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