{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:02:47Z","timestamp":1792598567674,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T00:00:00Z","timestamp":1226016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypocalcaemia after thyroidectomy is thought to result from surgical damage to the parathyroid glands. This study analysed postoperative outcomes related to perioperative parathyroid hormone (PTH) levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Some 402 consecutive patients undergoing thyroid surgery were studied prospectively to monitor perioperative changes in serum PTH and Ca2+ levels, and clinical symptoms of hypocalcaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Transient symptomatic hypocalcaemia and persistent hypoparathyroidism occurred in 61 (15 per cent) and six (1\u00b75 per cent) of 402 patients respectively. The intraoperative decline in PTH was 20\u00b72 per cent; the trough (63\u00b78 per cent of preoperative value) was reached 3 h after surgery. Before surgery, PTH levels were correlated inversely with serum Ca2+ concentration. The correlation remained positive from 3 h after surgery until postoperative day 14. Thus, PTH secretion was reduced, but remained sufficient to prevent symptomatic hypocalcaemia in most patients. A low serum PTH level was predictive of persistent hypoparathyroidism (sensitivity and negative predictive value 100 per cent, but poor specificity of 54\u00b71 per cent).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Thyroid surgery impairs hormone secretion by the parathyroid glands resulting in postoperative latent parathyroid insufficiency. Normal PTH levels 3 h after surgery and a normal serum calcium level on the first postoperative day rule out persistent hypoparathyroidism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6410","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T14:27:23Z","timestamp":1226068043000},"page":"1480-1487","source":"Crossref","is-referenced-by-count":78,"title":["Kinetics of serum parathyroid hormone during and after thyroid surgery"],"prefix":"10.1093","volume":"95","author":[{"given":"M","family":"Hermann","sequence":"first","affiliation":[{"name":"Department of Surgery, Kaiserin-Elisabeth-Spital, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaiserin-Elisabeth-Spital, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Promberger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaiserin-Elisabeth-Spital, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Kober","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaiserin-Elisabeth-Spital, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Karik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaiserin-Elisabeth-Spital, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Freissmuth","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Centre for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, 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