{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:11:36Z","timestamp":1771002696624,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T00:00:00Z","timestamp":1239148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hepatic artery embolization (HAE) is a palliative treatment for patients with liver metastases from neuroendocrine tumours. HAE reduces hormonal symptoms, but its impact on survival has been questioned.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Biochemical responses and survival in consecutive patients with disseminated liver metastases from midgut carcinoid tumours were studied after HAE. Repeat HAE was performed in selected patients with radiological and biochemical signs of progression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 107 patients who had HAE, the median survival from the first procedure was 56 (range 1\u2013204) months. Prolonged survival showed a strong correlation with reduction of urinary 5-hydroxyindoleacetic acid (P = 0\u00b7003) and plasma chromogranin A (P = 0\u00b7001) levels. The biochemical response to repeat HAE was similar to that for the first procedure (P = 0\u00b7002). The complication rate was low (7\u00b75 per cent), as was the mortality rate (1\u00b79 per cent) within 1 month of HAE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>HAE is safe, provides good control of hormonal symptoms, and prolongs survival in biochemically responsive patients. It is a valuable palliative option for patients with midgut carcinoid syndrome due to liver metastases and can be repeated in patients with a favourable response to the first procedure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6587","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T14:43:38Z","timestamp":1239201818000},"page":"517-521","source":"Crossref","is-referenced-by-count":42,"title":["Prolonged survival after hepatic artery embolization in patients with midgut carcinoid syndrome"],"prefix":"10.1093","volume":"96","author":[{"given":"C","family":"Sw\u00e4rd","sequence":"first","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Johanson","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Nieveen van Dijkum","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jansson","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Pathology, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"W\u00e4ngberg","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ahlman","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"K\u00f6lby","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Cancer Research, G\u00f6teborg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,4,8]]},"reference":[{"key":"2021070906252302600_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2214\/ajr.127.4.563","article-title":"Effects of experimental hepatic artery embolization on hepatic function","volume":"127","author":"Cho","year":"1976","journal-title":"AJR Am J Roentgenol"},{"key":"2021070906252302600_bib2","first-page":"407","article-title":"Technique and effects of portacaval anastomosis (Eck fistula)","volume":"95","author":"Markowitz","year":"1952","journal-title":"Surg Gynecol Obstet"},{"key":"2021070906252302600_bib3","first-page":"374","article-title":"Therapeutic hepatic artery ligation in patients with secondary liver tumors","volume":"23","author":"Nilsson","year":"1966","journal-title":"Rev Surg"},{"key":"2021070906252302600_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1148\/radiology.140.1.7244243","article-title":"Hepatic artery embolization in the treatment of hepatic neoplasms","volume":"140","author":"Chuang","year":"1981","journal-title":"Radiology"},{"key":"2021070906252302600_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1749-6632.1994.tb17298.x","article-title":"Neuroendocrine tumors metastatic to the liver. 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