{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:16:19Z","timestamp":1791267379487,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T00:00:00Z","timestamp":1249948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"UK Comprehensive Clinical Research Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim was to determine whether folate supplementation improved arterial function in patients with peripheral arterial disease (PAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individuals with PAD were randomly assigned to receive 400 \u00b5g folic acid (45 patients) or 5-methyltetrahydrofolate (5-MTHF) (48) daily, or placebo (40) for 16 weeks. Primary endpoints were changes in plasma total homocysteine (tHcy), ankle : brachial pressure index (ABPI) and pulse wave velocity (PWV). Secondary outcomes were changes in plasma inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma tHcy was significantly reduced in folic acid and 5-MTHF groups compared with controls: median difference: \u2212 2\u00b712 (95 per cent confidence interval \u2212 3\u00b770 to \u2212 0\u00b775) \u00b5mol\/l (P = 0\u00b7002) and \u2212 2\u00b707 (\u22123\u00b748 to \u2212 0\u00b754) \u00b5mol\/l (P = 0\u00b7007) respectively. ABPI improved significantly: median difference 0\u00b707 (0\u00b704 to 0\u00b711) (P &amp;lt; 0\u00b7001) and 0\u00b705 (0\u00b701 to 0\u00b710) (P = 0\u00b7009) respectively. Brachial\u2013knee PWV (bk-PWV) decreased significantly in individuals receiving 5-MTHF and tended to be reduced in those taking folic acid compared with controls: median difference: \u2212 1\u00b710 (\u22122\u00b720 to \u2212 0\u00b720) m\/s (P = 0\u00b7011) and \u2212 0\u00b790 (\u22122\u00b710 to 0\u00b700) m\/s (P = 0\u00b7051) respectively. Plasma levels of inflammatory markers were not affected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Folate administration reduced plasma homocysteine, and slightly improved ABPI and bk-PWV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.6670","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T13:15:37Z","timestamp":1249996537000},"page":"990-998","source":"Crossref","is-referenced-by-count":23,"title":["Randomized clinical trial of folate supplementation in patients with peripheral arterial disease"],"prefix":"10.1093","volume":"96","author":[{"given":"N","family":"Khandanpour","sequence":"first","affiliation":[{"name":"Vascular Unit, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK"},{"name":"School of Medicine and Health Policy and Practice, University of East Anglia, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"Armon","sequence":"additional","affiliation":[{"name":"Vascular Unit, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Jennings","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Policy and Practice, University of East Anglia, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P M","family":"Finglas","sequence":"additional","affiliation":[{"name":"Institute of Food Research, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Willis","sequence":"additional","affiliation":[{"name":"Molecular Genetics Laboratory, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Clark","sequence":"additional","affiliation":[{"name":"School of Medicine 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