{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:41Z","timestamp":1791928961882,"version":"4.3.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["67 631"],"award-info":[{"award-number":["67 631"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study investigated adhesive intestinal obstruction (AIO) and incisional hernia (IH) in patients undergoing laparoscopically assisted and open surgery for colorectal cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a case-note review of patients randomized to the Medical Research Council's Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, primary and key secondary endpoints were AIO and IH admission rates respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 411 patients, 11 were admitted for AIO: four (3\u00b71 per cent) of 131 patients in the open arm of the trial versus seven (2\u00b75 per cent) of 280 in the laparoscopic arm (difference 0\u00b76 (95 per cent confidence interval (c.i.) \u2212 2\u00b79 to 4\u00b70) per cent). Thirty-six patients developed IH: 12 (9\u00b72 per cent) after open versus 24 (8\u00b76 per cent) after laparoscopic surgery (difference 0\u00b76 (95 per cent c.i. \u2212 5\u00b73 to 6\u00b75) per cent). Results by actual procedure showed higher AIO and IH rates in the 24\u00b75 per cent of patients who converted from laparoscopic to open surgery (AIO: 2\u00b73, 2\u00b70 and 6 per cent; IH: 8\u00b76, 7\u00b74 and 11 per cent\u2014for open, laparoscopic and converted operations respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although this study has not confirmed that laparoscopic surgery reduces rates of AIO and IH after colorectal cancer surgery, trends suggest that a reduction in conversion to open surgery and elimination of port-site hernias may produce such an effect. Registration number for CLASICC trial: ISRCTN74883561 (http:\/\/www.controlled-trials.com).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6742","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T12:51:55Z","timestamp":1260449515000},"page":"70-78","source":"Crossref","is-referenced-by-count":149,"title":["Adhesions and incisional hernias following laparoscopic <i>versus<\/i> open surgery for colorectal cancer in the CLASICC trial"],"prefix":"10.1093","volume":"97","author":[{"given":"G W","family":"Taylor","sequence":"first","affiliation":[{"name":"Academic Unit of Medicine, Surgery and Anaesthesia, St James's University Hospital , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D G","family":"Jayne","sequence":"additional","affiliation":[{"name":"Academic Unit of Medicine, Surgery and Anaesthesia, St James's University Hospital , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Brown","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, University of Leeds , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, University of Leeds , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Brown","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, University of Leeds , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S C","family":"Dewberry","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, University of Leeds , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Darent Valley Hospital , Dartford,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Guillou","sequence":"additional","affiliation":[{"name":"Academic Unit of Medicine, Surgery and Anaesthesia, St James's University Hospital , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"2024093006492628600_bib1","first-page":"60","article-title":"Intestinal obstruction from adhesions\u2014how big is the problem?","volume":"72","author":"Menzies","year":"1990","journal-title":"Ann R Coll Surg Engl"},{"key":"2024093006492628600_bib2","first-page":"147","article-title":"Postoperative adhesions: their treatment and relevance in clinical practice","volume":"75","author":"Menzies","year":"1993","journal-title":"Ann R Coll Surg Engl"},{"key":"2024093006492628600_bib3","first-page":"9","article-title":"The magnitude of adhesion related problems","volume":"87","author":"Ellis","year":"1998","journal-title":"Ann Chir Gynaecol"},{"key":"2024093006492628600_bib4","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0140-6736(98)09337-4","article-title":"Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study","volume":"353","author":"Ellis","year":"1999","journal-title":"Lancet"},{"key":"2024093006492628600_bib5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1463-1318.2004.00709.x","article-title":"Colorectal surgery: the risk and burden of adhesion-related complications","volume":"6","author":"Parker","year":"2004","journal-title":"Colorectal Dis"},{"key":"2024093006492628600_bib6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1463-1318.2005.00857.x","article-title":"The SCAR-3 study: 5-year adhesion-related readmission risk following lower abdominal surgical procedures","volume":"7","author":"Parker","year":"2005","journal-title":"Colorectal Dis"},{"key":"2024093006492628600_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1046\/j.1463-1318.2002.00374.x","article-title":"Demonstrating the clinical and cost effectiveness of adhesion reduction strategies","volume":"4","author":"Wilson","year":"2002","journal-title":"Colorectal Dis"},{"key":"2024093006492628600_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/bjs.5224","article-title":"Manipulation of the small intestine as a cause of the increased inflammatory response after open compared with laparoscopic surgery","volume":"93","author":"Hiki","year":"2006","journal-title":"Br J Surg"},{"key":"2024093006492628600_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1072-7515(03)00232-1","article-title":"Does means of access affect the incidence of small bowel obstruction and ventral hernia after bowel resection? 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