{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:56:26Z","timestamp":1774270586634,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T00:00:00Z","timestamp":1258070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001168","name":"Cancer Council, Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001168","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In North Queensland demand for conservative faecal incontinence treatments outweighs supply. Injectable bulking agents offer a safe and effective treatment for patients with internal anal sphincter (IAS) dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Information, including age and sex, baseline incontinence score, quality of life, resting and squeeze pressures, was collected for 74 patients (37 men) who received intersphincteric PTQ\u2122 injections. Postimplant satisfaction was assessed at 6-week review. Incontinence scores and satisfaction ratings were determined annually.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median follow-up of 28 months, 52 patients (70 per cent) with IAS dysfunction who received PTQ\u2122 anal implants as a treatment for faecal incontinence were continent and extremely satisfied with the result. The incontinence score in participants who remained incontinent was reduced significantly from 12 of 20 before implant to 3\u00b75 of 20 at follow-up (P &amp;lt; 0\u00b7001). Migration rates improved with experience. The poorest results occurred in women with pudendal neuropathy, or patients who had previously received biofeedback treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implanted PTQ\u2122 provides an effective solution to faecal incontinence in the short and mid term for patients with IAS dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.6745","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T14:13:24Z","timestamp":1258121604000},"page":"1468-1475","source":"Crossref","is-referenced-by-count":35,"title":["PTQ\u2122 anal implants for the treatment of faecal incontinence"],"prefix":"10.1093","volume":"96","author":[{"given":"L","family":"Bartlett","sequence":"first","affiliation":[{"name":"School of Public Health, Tropical Medicine and Rehabilitation Science, James Cook University, Townsville, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-H","family":"Ho","sequence":"additional","affiliation":[{"name":"School of Medicine and the Australian Institute of Tropical Medicine within the North Queensland Centre for Cancer Research, James Cook University, Townsville, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,11,13]]},"reference":[{"key":"2021070910371255500_bib1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s10350-004-0593-0","article-title":"The prevalence of fecal incontinence in community-dwelling adults: a systematic review of the literature","volume":"47","author":"Macmillan","year":"2004","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1440-1854.2004.00642.x","article-title":"Faecal incontinence: an unrecognised epidemic in rural North Queensland? Results of a hospital-based outpatient study","volume":"13","author":"Ho","year":"2005","journal-title":"Aust J Rural Health"},{"key":"2021070910371255500_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10151-007-0360-z","article-title":"Reasons for non-disclosure of faecal incontinence: a comparison between two survey methods","volume":"11","author":"Bartlett","year":"2007","journal-title":"Tech Coloproctol"},{"key":"2021070910371255500_bib4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/bjs.5676","article-title":"Faecal incontinence","volume":"94","author":"Chatoor","year":"2007","journal-title":"Br J Surg"},{"key":"2021070910371255500_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/nau.20565","article-title":"Sacral nerve stimulation for fecal incontinence and constipation in adults: a short version Cochrane review","volume":"27","author":"Mowatt","year":"2008","journal-title":"Neurourol Urodyn"},{"key":"2021070910371255500_bib6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/MEG.0b013e32811ec010","article-title":"Temperature-controlled radiofrequency energy (SECCA) to the anal canal for the treatment of faecal incontinence offers moderate improvement","volume":"19","author":"Felt-Bersma","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2021070910371255500_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10350-007-9169-0","article-title":"SECCA procedure for the treatment of fecal incontinence: results of five-year follow-up","volume":"51","author":"Takahashi-Monroy","year":"2008","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/bjs.4997","article-title":"Injectable bulking agents for treating faecal incontinence","volume":"92","author":"Vaizey","year":"2005","journal-title":"Br J Surg"},{"key":"2021070910371255500_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF01646870","article-title":"The composition of anal basal pressure. An in vivo and in vitro study in man","volume":"4","author":"Lestar","year":"1989","journal-title":"Int J Colorectal Dis"},{"key":"2021070910371255500_bib10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/bjs.1800820507","article-title":"Haemorrhoidectomy and disordered rectal and anal physiology in patients with prolapsed haemorrhoids","volume":"82","author":"Ho","year":"1995","journal-title":"Br J Surg"},{"key":"2021070910371255500_bib11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1463-1318.2008.01634.x","article-title":"Injectable silicone biomaterial (PTQ\u2122) is more effective than carbon-coated beads (Durasphere) in treating passive faecal incontinence\u2014a randomised trial","volume":"11","author":"Tjandra","year":"2009","journal-title":"Colorectal Dis"},{"key":"2021070910371255500_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02050307","article-title":"Etiology and management of fecal incontinence","volume":"36","author":"Jorge","year":"1993","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib13","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1007\/s10350-004-0760-3","article-title":"Injectable silicone biomaterial for fecal incontinence caused by internal anal sphincter dysfunction is effective","volume":"47","author":"Tjandra","year":"2004","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1463-1318.2008.01544.x","article-title":"Intersphincteric injected silicone biomaterial implants: a treatment for faecal incontinence","volume":"11","author":"Soerensen","year":"2009","journal-title":"Colorectal Dis"},{"key":"2021070910371255500_bib15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1463-1318.2006.01164.x","article-title":"Long-term results of perianal silicone injection for faecal incontinence","volume":"9","author":"Maeda","year":"2007","journal-title":"Colorectal Dis"},{"key":"2021070910371255500_bib16","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1007\/s10350-007-9009-2","article-title":"Evolving therapy for fecal incontinence","volume":"50","author":"Tan","year":"2007","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1463-1318.2007.01276.x","article-title":"Evaluation of the use of PTQ implants for the treatment of incontinent patients due to internal anal sphincter dysfunction","volume":"10","author":"de la Portilla","year":"2008","journal-title":"Colorectal Dis"},{"key":"2021070910371255500_bib18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s10350-007-9170-7","article-title":"Carbon-coated microbeads anal injection in outpatient treatment of minor fecal incontinence","volume":"51","author":"Altomare","year":"2008","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10350-005-0307-2","article-title":"Injectable silicone biomaterial (PTQ) to treat fecal incontinence after hemorrhoidectomy","volume":"49","author":"Chan","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/bjs.5463","article-title":"PTQ implants in the treatment of faecal soiling","volume":"94","author":"van der Hagen","year":"2007","journal-title":"Br J Surg"},{"key":"2021070910371255500_bib21","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/BF02235272","article-title":"Perianal injection of polydimethylsiloxane (Bioplastique implants) paste in the treatment of soiling: pilot study in rats to determine migratory tendency and locoregional reaction","volume":"41","author":"Nijhuis","year":"1998","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02234835","article-title":"Treatment options for fecal incontinence","volume":"44","author":"Whitehead","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"2021070910371255500_bib23","volume-title":"Intersphincteric Injection of Silicone Biomaterial for Severe Passive Faecal Incontinence.","author":"Medical Services Advisory Committee, Department of Health and Ageing","year":"2006"},{"key":"2021070910371255500_bib24","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00120-004-0700-9","article-title":"Stem cell therapy for urinary incontinence","volume":"43","author":"Strasser","year":"2004","journal-title":"Urologe A"},{"key":"2021070910371255500_bib25","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1464-410X.2007.07119.x","article-title":"Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients","volume":"100","author":"Mitterberger","year":"2007","journal-title":"BJU Int"},{"key":"2021070910371255500_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.juro.2007.08.154","article-title":"Myoblast and fibroblast therapy for post-prostatectomy urinary incontinence: 1-year followup of 63 patients","volume":"179","author":"Mitterberger","year":"2008","journal-title":"J Urol"},{"key":"2021070910371255500_bib27","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1517\/14712598.8.9.1417","article-title":"Expanded adipose-derived stem cells for the treatment of complex perianal fistula including Crohn's disease","volume":"8","author":"Garcia-Olmo","year":"2008","journal-title":"Expert Opin Biol Ther"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.6745","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/96\/12\/1468\/36639171\/bjs6745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/96\/12\/1468\/36639171\/bjs6745.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T16:33:31Z","timestamp":1710693211000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/96\/12\/1468\/6141915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,13]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,11,13]]},"published-print":{"date-parts":[[2009,11,13]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.6745","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,12]]},"published":{"date-parts":[[2009,11,13]]}}}