{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:14Z","timestamp":1792782254107,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"\u2018Innovative Medical Research\u2019 of the University of Muenster Medical School","award":["KR 2 2 04 05"],"award-info":[{"award-number":["KR 2 2 04 05"]}],"id":[{"id":"https:\/\/ror.org\/00pd74e08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exogenously applied insulin-like growth factor (rhIGF-1) may improve normal intestinal healing. This study examined the effect of rhIGF-1-coated sutures on anastomotic healing in experimental colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Acute colitis was induced in rats by dextran sodium sulphate (DSS). Inflammation was assessed by clinical Disease Activity Index (DAI), myeloperoxidase (MPO) measurement and histological examination. A distal colonic anastomosis was performed using sutures coated with rhIGF-1 dissolved in poly(d,l-lactide) (PDLLA) under general anaesthetic. Anastomotic healing was evaluated histologically, and by hydroxyproline measurement and bursting parameters after 1, 3 and 7 days, and compared with healthy, DSS and DSS + PDLLA controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DAI, MPO and histological inflammation scores were significantly increased in all animals treated with DSS. Bursting occurred less often within the anastomotic line on day 3 in the IGF group than in DSS controls (three versus eight of ten). On day 7, the IGF group had significantly increased histological healing scores (mean(s.e.m.) 12\u00b75(0\u00b77) versus 9\u00b72(0\u00b78) (P &amp;lt; 0\u00b7050)) and hydroxyproline content (4\u00b76(0\u00b73) versus 3\u00b76(0\u00b71) mg\/g tissue; P &amp;lt; 0\u00b7050) compared with DSS controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IGF-1-coated sutures improve important aspects of anastomotic healing in rats with experimental colitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.6781","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T04:49:16Z","timestamp":1263876556000},"page":"258-265","source":"Crossref","is-referenced-by-count":24,"title":["Insulin-like growth factor 1-coated sutures improve anastomotic healing in an experimental model of colitis"],"prefix":"10.1093","volume":"97","author":[{"given":"E","family":"Rijcken","sequence":"first","affiliation":[{"name":"Department of General and Visceral Surgery, University of Muenster, Muenster, Germany"},{"name":"Section of Surgical Research, Department of General and Visceral Surgery, University of Muenster, Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University of Muenster, Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Sachs","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, University of Muenster, Muenster, Germany"},{"name":"Section of Surgical Research, Department of General and Visceral Surgery, University of Muenster, Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C 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