{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:36:16Z","timestamp":1791052576233,"version":"4.1.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T00:00:00Z","timestamp":1258070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100010659","name":"Mrace, Erasmus MC\u2014University Medical Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>About 24 per cent of phaeochromocytomas (PCCs) and sympathetic paragangliomas (sPGLs) appear in familial cancer syndromes, including multiple endocrine neoplasia type 2, von Hippel\u2013Lindau disease, neurofibromatosis type 1 and PCC\u2013paraganglioma syndrome. Identification of these syndromes is of prime importance for patients and their relatives. Surgical resection is the treatment of choice for both PCC and sPGL, but controversy exists about the management of patients with bilateral or multiple tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Relevant medical literature from PubMed, Ovid and Embase websites until 2009 was reviewed for articles on PCC, sPGL, hereditary syndromes and their treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Genetic testing for these syndromes should become routine clinical practice for those with PCC or sPGL. Patients should be referred to a clinical geneticist. Patients and family members with proven mutations should be entered into a standardized screening protocol. The preferred treatment of PCC and PGL is surgical resection; to avoid the lifelong consequences of bilateral adrenalectomy, cortex-sparing adrenalectomy is the treatment of choice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6821","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T14:13:24Z","timestamp":1258121604000},"page":"1381-1392","source":"Crossref","is-referenced-by-count":53,"title":["Phaeochromocytomas and sympathetic paragangliomas"],"prefix":"10.1093","volume":"96","author":[{"given":"B-J","family":"Petri","sequence":"first","affiliation":[{"name":"Department of Pathology, Erasmus MC\u2014University Medical Centre, Rotterdam, The Netherlands"},{"name":"Department of Surgery, Erasmus MC\u2014University Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H J","family":"van Eijck","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC\u2014University Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W W","family":"de Herder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC\u2014University Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus MC\u2014University Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R R","family":"de Krijger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC\u2014University Medical Centre, Rotterdam, The 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