{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:51:37Z","timestamp":1792299097741,"version":"4.4.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T00:00:00Z","timestamp":1263254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A recent systematic review found early laparoscopic cholecystectomy (ELC) to be safe and to shorten total hospital stay compared with delayed laparoscopic cholecystectomy (DLC) for acute cholecystitis. The cost-effectiveness of ELC versus DLC for acute cholecystitis is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A decision tree model estimating and comparing costs to the UK National Health Service (NHS) and quality-adjusted life years (QALYs) gained following a policy of either ELC or DLC was developed with a time horizon of 1 year. Uncertainty was investigated with probabilistic sensitivity analysis, and value-of-information analysis estimated the likely return from further investment in research in this area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ELC is less costly (approximately \u2212 \u00a3820 per patient) and results in better quality of life (+0\u00b705 QALYs per patient) than DLC. Given a willingness-to-pay threshold of \u00a320 000 per QALY gained, there is a 70\u00b79 per cent probability that ELC is cost effective compared with DLC. Full implementation of ELC could save the NHS \u00a38\u00b75 million per annum.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results of this decision analytic modelling study suggest that on average ELC is less expensive and results in better quality of life than DLC. Future research should focus on quality-of-life measures alone.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6872","type":"journal-article","created":{"date-parts":[[2009,12,24]],"date-time":"2009-12-24T11:37:25Z","timestamp":1261654645000},"page":"210-219","source":"Crossref","is-referenced-by-count":81,"title":["Cost\u2013utility and value-of-information analysis of early <i>versus<\/i> delayed laparoscopic cholecystectomy for acute cholecystitis"],"prefix":"10.1093","volume":"97","author":[{"given":"E","family":"Wilson","sequence":"first","affiliation":[{"name":"Health Economics Group, Faculty of Health, University of East Anglia , Norwich,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Gurusamy","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free Hospital, University College London Medical School , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gluud","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B R","family":"Davidson","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free Hospital, University College London Medical School , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"issue":"4","key":"2024093006441226500_bib1","first-page":"CD006231","article-title":"Laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis","author":"Keus","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"2024093006441226500_bib2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/archsurg.135.9.1021","article-title":"The spectrum and cost of complicated gallstone disease in California","volume":"135","author":"Glasgow","year":"2000","journal-title":"Arch Surg"},{"issue":"4","key":"2024093006441226500_bib3","first-page":"CD005440","article-title":"Early versus delayed laparoscopic cholecystectomy for acute cholecystitis","author":"Gurusamy","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"2024093006441226500_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/bjs.6870","article-title":"Meta-analysis of randomized controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute cholecystitis","volume":"97","author":"Gurusamy","year":"2009","journal-title":"Br J Surg"},{"key":"2024093006441226500_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00464-005-0100-2","article-title":"Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a metaanalysis","volume":"20","author":"Lau","year":"2006","journal-title":"Surg Endosc"},{"key":"2024093006441226500_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198529446.001.0001","volume-title":"Methods for the Economic Evaluation of Health Care Programmes","author":"Drummond","year":"2005","edition":"3rd"},{"key":"2024093006441226500_bib7","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1001\/archsurg.139.5.476","article-title":"Long-term detrimental effect of bile duct injury on health-related quality of life","volume":"139","author":"Moore","year":"2004","journal-title":"Arch Surg"},{"key":"2024093006441226500_bib8","article-title":"The Green Book","author":"Treasury","year":"2008","journal-title":"Appraisal and Evaluation in Central Government"},{"key":"2024093006441226500_bib9","volume-title":"Guide to the Methods of Technology Appraisal","author":"National Institute for Health and Clinical Excellence"},{"key":"2024093006441226500_bib10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/00365520310004056","article-title":"Acute cholecystitis: delayed surgery or observation. 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