{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:13:05Z","timestamp":1788869585640,"version":"build-2803163510"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T00:00:00Z","timestamp":1264377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"publisher","award":["0541195361"],"award-info":[{"award-number":["0541195361"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lymphoscintigraphy is widely used to image the lymphatic system. The aim of this study was to compare lymphoscintigraphy and dynamic magnetic resonance lymphangiography (MRL) in the investigation of extremity lymphoedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen patients with primary extremity lymphoedema and two with Klippel\u2013Trenaunay syndrome with lymphoedema were examined by lymphoscintigraphy using the tracer 99Tc-labelled dextran, and by MRL using gadobenate dimeglumine as contrast agent. Morphological abnormalities and functional state of the lymphatic systems of affected limbs were compared between the two imaging methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lymphatic vessels were imaged in 14 of 18 limbs with lymphoedema using MRL, compared with one of 18 using lymphoscintigraphy. MRL detected the inguinal nodes in 16 of 17 patients, whereas lymphoscintigraphy revealed inguinal nodes in only nine. MRL revealed more precise information about structural and functional abnormalities of lymph vessels and nodes than lymphoscintigraphy by real-time measurement of lymph flow in vessels and nodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dynamic MRL was more sensitive and accurate than lymphoscintigraphy in the detection of anatomical and functional abnormalities in the lymphatic system in patients with extremity lymphoedema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.6893","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T06:22:35Z","timestamp":1264400555000},"page":"359-365","source":"Crossref","is-referenced-by-count":55,"title":["Comparison of radionuclide lymphoscintigraphy and dynamic magnetic resonance lymphangiography for investigating extremity lymphoedema"],"prefix":"10.1093","volume":"97","author":[{"given":"N-F","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Ren Ji Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-A","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Ninth People's Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X-F","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B-S","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,1,25]]},"reference":[{"key":"2021070906523472900_bib1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/1097-0142(195311)6:6<1238::AID-CNCR2820060618>3.0.CO;2-6","article-title":"Lymph node concentration of radioactive colloidal gold following interstial injection","volume":"6","author":"Sherman","year":"1953","journal-title":"Cancer"},{"key":"2021070906523472900_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jvs.2004.11.013","article-title":"Noncontrast three-dimensional magnetic resonance imaging vs lymphoscintigraphy in the evaluation of lymph circulation disorders: a comparative study","volume":"41","author":"Liu","year":"2005","journal-title":"J Vasc Surg"},{"key":"2021070906523472900_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/cmmi.116","article-title":"Imaging of the lymphatic system: new horizons","volume":"1","author":"Barrett","year":"2006","journal-title":"Contrast Media Mol Imaging"},{"key":"2021070906523472900_bib4","first-page":"111","article-title":"Magnetic resonance imaging as a new method to diagnose protein losing enteropathy","volume":"41","author":"Liu","year":"2008","journal-title":"Lymphology"},{"key":"2021070906523472900_bib5","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jvs.2008.11.029","article-title":"Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography","volume":"49","author":"Liu","year":"2009","journal-title":"J Vasc Surg"},{"key":"2021070906523472900_bib6","article-title":"Chronic lower extremity lymphedema: a comparative study of high-resolution interstitial MR lymphangiography and heavily T2-weighted MRI","author":"Lu","year":"2008","journal-title":"Eur J Radiol"},{"key":"2021070906523472900_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/CS20000275","article-title":"Differences in lymph drainage between swollen and non-swollen regions in arms with breast-cancer-related lymphoedema","volume":"101","author":"Stanton","year":"2001","journal-title":"Clin Sci (Lond)"},{"key":"2021070906523472900_bib8","first-page":"13","article-title":"Lymphangiography in man; a method of outlining lymphatic trunks at operation","volume":"11","author":"Kinmonth","year":"1952","journal-title":"Clin Sci (Lond)"},{"key":"2021070906523472900_bib9","volume-title":"The Lymphatics, Diseases, Lymphography, and Surgery","author":"Kinmonth","year":"1972"},{"key":"2021070906523472900_bib10","first-page":"278","article-title":"Lymph nodes and vessels in primary lymphoedema. 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