{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:09:54Z","timestamp":1790104194382,"version":"4.0.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T00:00:00Z","timestamp":1271894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004572","name":"Chinese Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Specific immunonutrients may reduce the incidence of postoperative complications and shorten recovery time. This randomized trial evaluated the clinical efficacy of a fish oil emulsion on outcome and immune function after gastrointestinal cancer surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 206 patients with gastrointestinal or colonic cancer were randomized to receive isocaloric and isonitrogenous intravenous infusions of either soybean oil alone (1\u00b72 g per kg bodyweight per day; control group, 103 analysed) or soybean plus fish oil emulsion (1\u00b70 and 0\u00b72 g per kg per day respectively; treatment group, 100 analysed) over 20\u201324 h daily for 7 days after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Baseline data were comparable in the two groups. There were fewer infectious complications (four versus 12 on day 8; P = 0\u00b7066), systemic inflammatory response syndrome (SIRS) was significantly less common (four versus 13; P = 0\u00b7039) and hospital stay was significantly shorter (mean(s.d.) 15(5) versus 17(8) days; P = 0\u00b7041) in the treatment group. Total postoperative medical costs were comparable in the two groups (mean(s.d.) US $ 1269(254) and 1302(324) in treatment and control groups respectively; P = 0\u00b7424). The median (interquartile range) difference in CD4\/CD8 between days 1 and 8 after surgery was + 0\u00b730 (0\u00b706 to 0\u00b779) in patients receiving fish oil and + 0\u00b720 (\u22120\u00b719 to 0\u00b755) in controls (P = 0\u00b7021). No severe adverse events occurred in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Fish oil emulsion-supplemented parenteral nutrition significantly reduced SIRS and length of hospital stay. These clinical benefits may be related to normalization of cellular immune functions and modulation of the inflammatory response. Registration number: NCT00292279 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6999","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T20:05:29Z","timestamp":1271966729000},"page":"804-809","source":"Crossref","is-referenced-by-count":71,"title":["Randomized clinical trial of intravenous soybean oil alone <i>versus<\/i> soybean oil plus fish oil emulsion after gastrointestinal cancer surgery"],"prefix":"10.1093","volume":"97","author":[{"given":"Z M","family":"Jiang","sequence":"first","affiliation":[{"name":"Departments of Surgery and Parenteral and Enteral Nutrition, Department of Nutrition, and Centre for Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Wilmore","sequence":"additional","affiliation":[{"name":"Brigham and 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