{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:18Z","timestamp":1788870078648,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T00:00:00Z","timestamp":1271894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003761","name":"University Medical Center Utrecht PhD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-erosive (NERD) and erosive (ERD) gastro-oesophageal reflux disease (GORD) show similar severity of symptoms and impact on quality of life (QoL). Prospective data on long-term outcomes of antireflux surgery in NERD are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjective and objective 5-year outcomes of Nissen fundoplication were compared in 96 patients with NERD and 117 with ERD, operated on for proton-pump inhibitor (PPI)-refractory GORD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preoperative and postoperative QoL, PPI use, acid exposure time, symptom\u2013reflux correlation, lower oesophageal sphincter (LOS) pressure and reoperation rates were similar in the two groups. At 5 years, relief of reflux symptoms was similar (NERD 89 per cent versus ERD 96 per cent), PPI use showed a similar reduction (82 to 21 per cent versus 81 to 15 per cent respectively; both P &amp;lt; 0\u00b7001) and QoL score improved equally (50\u00b73 to 65\u00b72 (P &amp;lt; 0\u00b7001) versus 52\u00b70 to 60\u00b77 (P = 0\u00b7016)). Five patients with NERD developed erosions after surgery; oesophagitis healed in 87 per cent of patients with ERD. Reduction in total acid exposure time (NERD 12\u00b77 to 2\u00b70 per cent versus ERD 13\u00b78 to 2\u00b79 per cent; both P &amp;lt; 0\u00b7001) and increase in LOS pressure (1\u00b73 to 1\u00b78 kPa versus 1\u00b72 to 1\u00b78 kPa; both P &amp;lt; 0\u00b7001) were similar. The reintervention rate was comparable (NERD 15 per cent versus ERD 12\u00b78 per cent).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with PPI-refractory NERD and ERD benefit equally from Nissen fundoplication. The absence of mucosal lesions on endoscopy in patients with proven PPI-refractory reflux disease is not a reason to refrain from antireflux surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.7023","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T16:05:29Z","timestamp":1271952329000},"page":"845-852","source":"Crossref","is-referenced-by-count":52,"title":["Long-term outcome of Nissen fundoplication in non-erosive and erosive gastro-oesophageal reflux disease"],"prefix":"10.1093","volume":"97","author":[{"given":"J A","family":"Broeders","sequence":"first","affiliation":[{"name":"Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W A","family":"Draaisma","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Research Unit, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Research Unit, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I A","family":"Broeders","sequence":"additional","affiliation":[{"name":"Department of Surgery, Meander Medical Center, Amersfoort, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H G","family":"Gooszen","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,22]]},"reference":[{"key":"2021070906531355300_bib1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/gut.45.2.172","article-title":"Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification","volume":"45","author":"Lundell","year":"1999","journal-title":"Gut"},{"key":"2021070906531355300_bib2","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","article-title":"The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus","volume":"101","author":"Vakil","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"2021070906531355300_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/13814789509161628","article-title":"Gastro-esophageal reflux disease in primary care in Europe: clinical presentation and endoscopic findings","volume":"1","author":"Jones","year":"1995","journal-title":"Eur J Gen Pract"},{"key":"2021070906531355300_bib4","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3109\/00365529709011212","article-title":"Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response","volume":"32","author":"Lind","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"2021070906531355300_bib5","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1111\/j.1572-0241.1999.01206.x","article-title":"Quality of life in patients with heartburn but without esophagitis: effects of treatment with omeprazole","volume":"94","author":"Havelund","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"2021070906531355300_bib6","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/S0002-9270(01)02591-6","article-title":"Quality of life in patients with gastroesophageal reflux disease","volume":"96","author":"Wiklund","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"2021070906531355300_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00042737-199802000-00004","article-title":"Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. 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