{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:49Z","timestamp":1788872329131,"version":"build-2803163510"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T00:00:00Z","timestamp":1272412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Polish State Committee for Scientific Research","award":["3 P05C 067 23p01"],"award-info":[{"award-number":["3 P05C 067 23p01"]}]},{"name":"Polish State Committee for Scientific Research","award":["2 P05C 024 29"],"award-info":[{"award-number":["2 P05C 024 29"]}]},{"name":"Polish State Committee for Scientific Research","award":["3 P05C 031 22"],"award-info":[{"award-number":["3 P05C 031 22"]}]},{"name":"Polish State Committee for Scientific Research","award":["N403 069 31\/3255"],"award-info":[{"award-number":["N403 069 31\/3255"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent studies suggest that anastomotic leak may adversely affect long-term survival in patients undergoing surgery for gastrointestinal malignancies. Data relating to total gastrectomy for gastric cancer are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An electronic database of all patients with resectable gastric cancer treated between January 1999 and December 2004 at seven university surgical centres cooperating in the Polish Gastric Cancer Study Group was reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anastomotic leakage was diagnosed in 41 (5\u00b79 per cent) of 690 patients who underwent total gastrectomy. The prevalence of surgical and general complications, and mortality rates were significantly higher in patients diagnosed with anastomotic leakage. The only two independent risk factors for leakage were Eastern Cooperative Oncology Group performance status of 2 or 3 (odds ratio 5\u00b709, 95 per cent confidence interval (c.i.) 2\u00b729 to 11\u00b732) and splenectomy (odds ratio 2\u00b758, 95 per cent c.i. 1\u00b708 to 6\u00b713). Two Cox proportional hazards models including all the patients and excluding in-hospital deaths identified anastomotic leakage as an independent predictor of survival with hazard ratios of 3\u00b747 (95 per cent c.i. 1\u00b782 to 6\u00b764) and 3\u00b714 (1\u00b751\u20136\u00b753) respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The occurrence of anastomotic leakage was a major independent prognostic factor for long-term survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.7038","type":"journal-article","created":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T11:48:12Z","timestamp":1272541692000},"page":"1035-1042","source":"Crossref","is-referenced-by-count":201,"title":["Impact of anastomotic leakage on long-term survival after total gastrectomy for carcinoma of the stomach"],"prefix":"10.1093","volume":"97","author":[{"name":"Polish Gastric Cancer Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sierzega","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Jagiellonian University Medical College, 40 Kopernika Street, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Kolodziejczyk","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Jagiellonian University Medical College, 40 Kopernika Street, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kulig","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Jagiellonian University Medical College, 40 Kopernika Street, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,28]]},"reference":[{"key":"2021070906553803800_bib1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00423-005-0575-2","article-title":"Insufficiency risk of esophagojejunal anastomosis after total abdominal gastrectomy for gastric carcinoma","volume":"390","author":"Meyer","year":"2005","journal-title":"Langenbecks Arch Surg"},{"key":"2021070906553803800_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jamcollsurg.2005.02.002","article-title":"Mortality and morbidity after resection for adenocarcinoma of the gastroesophageal junction: predictive factors","volume":"201","author":"Sauvanet","year":"2005","journal-title":"J Am Coll Surg"},{"key":"2021070906553803800_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/ejso.1999.0764","article-title":"Management and results of proximal anastomotic leaks in a series of 1114 total gastrectomies for gastric carcinoma","volume":"26","author":"Lang","year":"2000","journal-title":"Eur J Surg Oncol"},{"key":"2021070906553803800_bib4","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s10350-004-0869-4","article-title":"Prognosis after anastomotic leakage in colorectal surgery","volume":"48","author":"Branagan","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"2021070906553803800_bib5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s005950050187","article-title":"Poor prognosis in esophageal cancer patients with postoperative complications","volume":"28","author":"Hirai","year":"1998","journal-title":"Surg Today"},{"key":"2021070906553803800_bib6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01.sla.0000133186.81222.08","article-title":"Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer","volume":"240","author":"Walker","year":"2004","journal-title":"Ann Surg"},{"key":"2021070906553803800_bib7","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/1097-0142(19931001)72:7<2089::AID-CNCR2820720706>3.0.CO;2-H","article-title":"Prognostic factors in gastric carcinoma. 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