{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:55:08Z","timestamp":1790517308644,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T00:00:00Z","timestamp":1278979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The UK Medical Research Council CLASICC trial assessed the safety and efficacy of laparoscopically assisted surgery in comparison with open surgery for colorectal cancer. The results of the 5-year follow-up analysis are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five-year outcomes were analysed and included overall and disease-free survival, and local, distant and wound\/port-site recurrences. Two exploratory analyses were performed to evaluate the effect of age (70 years or less, or more than 70 years) on overall survival between the two groups, and the effect of the learning curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No differences were found between laparoscopically assisted and open surgery in terms of overall survival, disease-free survival, and local and distant recurrence. Wound\/port-site recurrence rates in the laparoscopic arm remained stable at 2\u00b74 per cent. Conversion to open operation was associated with significantly worse overall but not disease-free survival, which was most marked in the early follow-up period. The effect of surgery did not differ between the age groups, and surgical experience did not impact on the 5-year results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 5-year analyses confirm the oncological safety of laparoscopic surgery for both colonic and rectal cancer. The use of laparoscopic surgery to maximize short-term outcomes does not compromise the long-term oncological results. Registration number: ISRCTN74883561 (http:\/\/www.controlled-trials.com).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.7160","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T15:20:41Z","timestamp":1279034441000},"page":"1638-1645","source":"Crossref","is-referenced-by-count":868,"title":["Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted\n                    <i>versus<\/i>\n                    open surgery for colorectal cancer"],"prefix":"10.1093","volume":"97","author":[{"given":"D G","family":"Jayne","sequence":"first","affiliation":[{"name":"Section of Translational Anaesthesia and Surgery, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H C","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Copeland","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Quirke","sequence":"additional","affiliation":[{"name":"Department of Pathology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Brown","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Guillou","sequence":"additional","affiliation":[{"name":"Section of Translational Anaesthesia and Surgery, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,13]]},"reference":[{"key":"2021070910434037500_bib1","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1056\/NEJMoa032651","article-title":"A comparison of laparoscopically assisted and open colectomy for colon cancer","volume":"350","author":"Clinical Outcomes of Surgical Therapy Study Group","year":"2004","journal-title":"N Engl J Med"},{"key":"2021070910434037500_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1470-2045(05)70221-7","article-title":"Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial","volume":"6","author":"Veldkamp","year":"2005","journal-title":"Lancet Oncol"},{"key":"2021070910434037500_bib3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1046\/j.1365-2168.2001.01781.x","article-title":"Randomized clinical trial of the effect of open versus laparoscopically assisted colectomy on systemic immunity in patients with colorectal cancer","volume":"88","author":"Tang","year":"2001","journal-title":"Br J Surg"},{"key":"2021070910434037500_bib4","volume-title":"Guidance on the Use of Laparoscopic Surgery for Colorectal Cancer. 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