{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:26:51Z","timestamp":1770823611630,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100010329","name":"Stichting Heelkundig Kankeronderzoek Zuid-Nederland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine the value of the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram for individual decision making in a Dutch cohort of women with breast cancer with a positive sentinel lymph node (SLN) but at low risk of additional nodal metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected on 168 patients with a positive SLN who underwent completion axillary lymph node dissection. The predicted probability of non-SLN metastases was calculated for each patient, using the MSKCC nomogram. Specificity and false-negative rates were calculated for subgroups with a predicted risk of no more than 5, 10 or 15 per cent. A receiver operating characteristic (ROC) curve was constructed and the area under the curve (AUC) calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The discrimination of the MSKCC nomogram, measured by the AUC, was 0\u00b768. For low predicted probability cut-off values of no more than 5, 10 and 15 per cent, the false-negative rates were 20, 14 and 19 per cent, and the specificities were 4, 27 and 32 per cent, respectively. The low-risk category (5 per cent or less) consisted of only 3\u00b70 per cent of the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The performance of the MSKCC nomogram was insufficient to make it a useful tool for individual decision making in this cohort of women with SLN-positive breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.7186","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T10:55:35Z","timestamp":1279277735000},"page":"1653-1658","source":"Crossref","is-referenced-by-count":20,"title":["Value of Memorial Sloan-Kettering Cancer Center nomogram in clinical decision making for sentinel lymph node-positive breast cancer"],"prefix":"10.1093","volume":"97","author":[{"given":"I","family":"van den Hoven","sequence":"first","affiliation":[{"name":"Department of Surgery, M\u00e1xima Medical Centre, Veldhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G P","family":"Kuijt","sequence":"additional","affiliation":[{"name":"Department of Surgery, M\u00e1xima Medical Centre, Veldhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Voogd","sequence":"additional","affiliation":[{"name":"Eindhoven Cancer Registry, Eindhoven, and Maastricht University Medical Centre, School GROW, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M W P M","family":"van Beek","sequence":"additional","affiliation":[{"name":"Laboratory for Pathology and Medical Microbiology, Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M H","family":"Roumen","sequence":"additional","affiliation":[{"name":"Department of Surgery, M\u00e1xima Medical Centre, Veldhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"2021070910400717900_bib1","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/1097-0142(19831101)52:9<1551::AID-CNCR2820520902>3.0.CO;2-3","article-title":"Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. 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