{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:29:06Z","timestamp":1761290946539},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Korea Healthcare Technology Research and Development Project"},{"name":"Ministry of Health and Welfare, Korea","award":["A084067"],"award-info":[{"award-number":["A084067"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Inflammation frequently accompanies gallbladder carcinoma (GBC), but its impact on outcome is unclear. The present study investigated the impact of concomitant inflammation on survival of patients with GBC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients undergoing surgery for GBC between October 2003 and May 2009 were identified retrospectively from a prospectively collected database. Patients were classified according to whether preoperative inflammation was present (65 patients) or not (23).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 88 patients were enrolled. There were no differences in sex, mean age, tumour node metastasis (TNM) stage and radicality of resection between the two groups. The overall 3-year survival rate was lower in patients with preoperative inflammation than in those without (33 versus 73 per cent; P = 0\u00b7001). In univariable analysis, preoperative inflammation, T, N and M category, TNM stage, radicality of surgery and tumour differentiation were significant prognostic factors. The presence of preoperative inflammation (hazard ratio (HR) 2\u00b738, 95 per cent confidence interval 1\u00b704 to 5\u00b743), lymph node metastases (HR 5\u00b723, 1\u00b705 to 26\u00b709) and R1 or R2 resection (HR 3\u00b777, 1\u00b747 to 9\u00b772) were independent prognostic factors for poor survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The presence of preoperative inflammation is an independent prognostic factor for poor survival in patients with GBC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.7265","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T12:51:08Z","timestamp":1288356668000},"page":"111-116","source":"Crossref","is-referenced-by-count":30,"title":["Preoperative inflammation is a prognostic factor for gallbladder carcinoma"],"prefix":"10.1093","volume":"98","author":[{"given":"H-S","family":"Han","sequence":"first","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seoul,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Y","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seoul,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-S","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seoul,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K S","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seoul,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seoul,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"2024093006362976700_bib1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"2024093006362976700_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"2024093006362976700_bib3","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/bjs.5706","article-title":"Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer","volume":"94","author":"Crozier","year":"2007","journal-title":"Br J Surg"},{"key":"2024093006362976700_bib4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/01.sla.0000154118.07704.ef","article-title":"An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center","volume":"241","author":"Dixon","year":"2005","journal-title":"Ann Surg"},{"key":"2024093006362976700_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2168.2002.02001.x","article-title":"Extensive surgery for carcinoma of the gallbladder","volume":"89","author":"Kondo","year":"2002","journal-title":"Br J Surg"},{"key":"2024093006362976700_bib6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00000658-199403000-00007","article-title":"Surgical treatment of 724 carcinomas of the gallbladder. 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