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Prospectively registered secondary endpoints bodyweight, symptom scores and respiratory function were evaluated in the present study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bodyweight was comparable after D2 and D2 plus PAND, but higher after TH than after LTA procedures at 1 and 3 years. At 1- and 3-year follow-up symptom scores were comparable between D2 and D2 plus PAND. A LTA approach resulted in significantly worse scores than a TH approach in terms of meal volume, return to work, incisional pain and dyspnoea up to 1 year. The decrease in vital capacity was significantly greater after LTA than TH procedures up to 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bodyweight and postoperative symptoms were not affected by adding PAND to a D2 procedure. A LTA approach aggravated weight loss, symptoms and respiratory functions compared with a TH approach. Registration numbers: NCT00149279, NCT00149266 (http:\/\/www.clinicaltrials.gov).<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.7297","type":"journal-article","created":{"date-parts":[[2010,11,22]],"date-time":"2010-11-22T14:00:25Z","timestamp":1290434425000},"page":"239-245","source":"Crossref","is-referenced-by-count":20,"title":["Functional outcomes after extended surgery for gastric cancer"],"prefix":"10.1093","volume":"98","author":[{"name":"Japan Clinical Oncology Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Osaka National Hospital , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sasako","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hyogo College of Medicine , 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