{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:39:30Z","timestamp":1790948370790,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Morbidity and mortality rates in patients with perforated peptic ulcer (PPU) remain substantial. The aim of the present study was to evaluate the effect of a multimodal and multidisciplinary perioperative care protocol on mortality in patients with PPU.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was an externally controlled multicentre trial set in seven gastrointestinal departments in Denmark. Consecutive patients who underwent surgery for gastric or duodenal PPU between 1 January 2008 and 31 December 2009 were treated according to a multimodal and multidisciplinary evidence-based perioperative care protocol. The 30-day mortality rate in this group was compared with rates in historical and concurrent national controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 30-day mortality rate following PPU was 17\u00b71 per cent in the intervention group, compared with 27\u00b70 per cent in the three control groups (P = 0\u00b7005). This corresponded to a relative risk of 0\u00b763 (95 per cent confidence interval 0\u00b741 to 0\u00b797), a relative risk reduction of 37 (5 to 58) per cent and a number needed to treat of 10 (6 to 38).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The 30-day mortality rate in patients with PPU was reduced by more than one-third after the implementation of a multimodal and multidisciplinary perioperative care protocol, compared with conventional treatment. Registration number: NCT00624169 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.7429","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T12:18:25Z","timestamp":1301055505000},"page":"802-810","source":"Crossref","is-referenced-by-count":151,"title":["Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation"],"prefix":"10.1093","volume":"98","author":[{"given":"M H","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Herlev, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Adamsen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Copenhagen University Hospital Herlev, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R 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