{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:53:14Z","timestamp":1758635594722},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T00:00:00Z","timestamp":1300147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Meta-analyses have indicated that preoperative mechanical bowel preparation (MBP) confers no clear benefit and may indeed be harmful for patients with colorectal cancer. The effects of bowel preparation on longer-term outcomes have not been reported. The aim was to compare long-term survival and surgical complications in patients who did or did not receive MBP before surgery for colonic cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective cohort study of all patients undergoing potentially curative surgery for colonic cancer after routine hospital admission in the West of Scotland between January 2000 and December 2005. Clinical audit data were linked to cancer registrations and death certificates. Kaplan\u2013Meier and Cox proportional hazards models were used to explore determinants of survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1730 patients underwent potentially curative surgery for colonic cancer, of whom 886 (51\u00b72 per cent) were men. The mean(s.d.) age was 69\u00b77(10\u00b76) years. Some 1460 patients (84\u00b74 per cent) received MBP. Median follow-up was 3\u00b75 (range 0\u00b71\u20136\u00b77) years. There were no statistically significant differences in 30-day postoperative complication rates between groups. The unadjusted hazard ratio (HR) for death from all causes for patients treated with MBP (versus no MBP) was 0\u00b772 (95 per cent confidence interval 0\u00b757 to 0\u00b791). Multivariable analysis with adjustment for age, sex, socioeconomic circumstances, disease stage and presentation for surgery showed that MBP had no independent effect on all-cause mortality (HR 0\u00b785, 0\u00b767 to 1\u00b710).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Neither postoperative complications nor long-term survival are improved by MBP before colonic cancer surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.7454","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T11:50:26Z","timestamp":1300189826000},"page":"866-871","source":"Crossref","is-referenced-by-count":19,"title":["Mechanical bowel preparation does not influence outcomes following colonic cancer resection"],"prefix":"10.1093","volume":"98","author":[{"given":"G A","family":"Nicholson","sequence":"first","affiliation":[{"name":"West of Scotland Cancer Surveillance Unit, Section of Public Health and Health Policy, Faculty of Medicine, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I G","family":"Finlay","sequence":"additional","affiliation":[{"name":"Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Diament","sequence":"additional","affiliation":[{"name":"Department of Surgery, Crosshouse Hospital, Kilmarnock, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Molloy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gartnavel General Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Horgan","sequence":"additional","affiliation":[{"name":"Department of Academic Surgery, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D S","family":"Morrison","sequence":"additional","affiliation":[{"name":"West of Scotland Cancer Surveillance Unit, Section of Public Health and Health Policy, Faculty of Medicine, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"2021070907003928700_bib1","first-page":"323","article-title":"Preoperative preparation of the colon","volume":"132","author":"Nichols","year":"1971","journal-title":"Surg Gynecol Obstet"},{"key":"2021070907003928700_bib2","first-page":"(1)CD001544","article-title":"Mechanical bowel preparation for elective colorectal surgery","author":"Guenaga","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"2021070907003928700_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/bjs.1800600612","article-title":"Aetiology of disruption of intestinal anastomoses","volume":"60","author":"Irvin","year":"1973","journal-title":"Br J 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