{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:42:17Z","timestamp":1787503337551,"version":"build-2736575974"},"reference-count":130,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T00:00:00Z","timestamp":1303257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypothermia, acidosis and coagulopathy have long been considered critical combinations after severe injury. The aim of this review was to give a clinical update on this triad in severely injured patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A non-systematic literature search on hypothermia, acidosis and coagulopathy after major injury was undertaken, with a focus on clinical data from the past 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hypothermia (less than 35 \u00b0C) is reported in 1\u00b76\u201313\u00b73 per cent of injured patients. The occurrence of acidosis is difficult to estimate, but usually follows other physiological disturbances. Trauma-induced coagulopathy (TIC) has both endogenous and exogenous components. Endogenous acute traumatic coagulopathy is associated with shock and hypoperfusion. Exogenous effects of dilution from fluid resuscitation and consumption through bleeding and loss of coagulation factors further add to TIC. TIC is present in 10\u201334 per cent of injured patients, depending on injury severity, acidosis, hypothermia and hypoperfusion. More expedient detection of coagulopathy is needed. Thromboelastography may be a useful point-of-care measurement. Management of TIC is controversial, with conflicting reports on blood component therapy in terms of both outcome and ratios of blood products to other fluids, particularly in the context of civilian trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The triad of hypothermia, acidosis and coagulopathy after severe trauma appears to be fairly rare but does carry a poor prognosis. Future research should define modes of early detection and targeted therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.7497","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T14:02:45Z","timestamp":1303308165000},"page":"894-907","source":"Crossref","is-referenced-by-count":80,"title":["Clinical and cellular effects of hypothermia, acidosis and coagulopathy in major injury"],"prefix":"10.1093","volume":"98","author":[{"given":"K","family":"Thorsen","sequence":"first","affiliation":[{"name":"Department of Surgery, Stavanger University Hospital, Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K G","family":"Ringdal","sequence":"additional","affiliation":[{"name":"Department of Research, Norwegian Air Ambulance Foundation, Dr\u00f8bak, Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Stavanger University Hospital, Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"S\u00f8reide","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Stavanger University Hospital, Stavanger, Norway"},{"name":"Department of Surgical Sciences, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hagemo","sequence":"additional","affiliation":[{"name":"Department of Research, Norwegian Air Ambulance Foundation, Dr\u00f8bak, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"S\u00f8reide","sequence":"additional","affiliation":[{"name":"Department of Surgery, Stavanger University Hospital, Stavanger, Norway"},{"name":"Department of Surgical Sciences, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,4,20]]},"reference":[{"key":"2021070910511711300_bib1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/bjs.6643","article-title":"Epidemiology of major trauma","volume":"96","author":"S\u00f8reide","year":"2009","journal-title":"Br J Surg"},{"key":"2021070910511711300_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00068-008-8080-2","article-title":"Hemorrhage is more prevalent than brain injury in early trauma deaths: the golden six hours","volume":"1","author":"Bansal","year":"2009","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2021070910511711300_bib3","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.injury.2008.03.033","article-title":"Applicability of the trimodal distribution of trauma deaths in a Level I trauma centre in the Netherlands with a population of mainly blunt trauma","volume":"39","author":"de Knegt","year":"2008","journal-title":"Injury"},{"key":"2021070910511711300_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.injury.2007.05.022","article-title":"Is the trimodal pattern of death after trauma a dated concept in the 21st century? 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