{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:59:19Z","timestamp":1761101959957},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study examined the interaction between natural history, current practice patterns in diagnosis, monitoring and treatment of oesophageal cancer, and associated health resource utilization and costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cost analysis of a prospective population-based cohort of 1100 patients with a primary diagnosis of oesophageal cancer was performed using chart review from the Australian Cancer Study Clinical Follow-Up Study. The analysis enabled estimation of healthcare resources and associated costs in 2009 euros by stage of disease and treatment pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients (88\u00b75 per cent) presented with stage II, III or IV cancer; 61\u00b71 per cent (672 of 1100) were treated surgically. Overall mean costs were \u20ac37 195 (median \u20ac29 114) for patients undergoing surgery and \u20ac17 281 (median \u20ac13 066) for those treated without surgery. Surgery contributed 66\u00b74 per cent of the total costs (mean \u20ac24 697 per patient) in the surgical group. In the non-surgical group, use of chemotherapy was more prevalent (81\u00b79 per cent of patients) and contributed 61\u00b71 per cent of the total costs. Other important cost determinants were gastro-oesophageal junction tumours, treatment location and tumour stage. Mean costs of those monitored for Barrett's oesophagus (7\u00b73 per cent of patients) were lower, although about one-third still presented with advanced-stage cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall costs for managing oesophageal cancer were high and dominated by surgery costs in patients treated surgically and by chemotherapy costs in patients treated without surgery. Radiotherapy, treatment location and cancer subtype were also important. Monitoring for Barrett's oesophagus and earlier-stage detection were associated with lower management costs, but the potential net benefit from surveillance strategies needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.7599","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T10:58:39Z","timestamp":1313578719000},"page":"1589-1598","source":"Crossref","is-referenced-by-count":17,"title":["Healthcare resource use and medical costs for the management of oesophageal cancer"],"prefix":"10.1093","volume":"98","author":[{"name":"Australian Cancer Study Clinical Follow-Up Study","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L G","family":"Gordon","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Population Health Department, Royal Brisbane Hospital, Brisbane, Queensland, Australia"},{"name":"Centre for Applied Health Economics, Griffith 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