{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:03:25Z","timestamp":1791831805406,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T00:00:00Z","timestamp":1310342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Vascular inflow occlusion is effective in avoiding excessive blood loss during hepatic parenchymal transection but may cause ischaemic damage to the remnant liver. Intermittent portal triad clamping (IPTC) is superior to continuous hepatic pedicle clamping as it avoids severe ischaemia\u2013reperfusion (IR) injury in the liver remnant. Ischaemic preconditioning (IPC) before continuous Pringle manoeuvre may protect against IR during major liver resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This RCT assessed the impact of IPC in major liver resection with intermittent vascular inflow occlusion. Patients undergoing major liver resection with intermittent vascular inflow occlusion were randomized, during surgery, to receive IPC (10 min inflow occlusion followed by 10 min reperfusion) or no IPC (control group). Data analysis was on an intention-to-treat basis. The primary endpoint was serum alanine aminotransferase (ALT) level on the day after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty four patients were enrolled and randomized to IPC (n = 41) and no IPC (n = 43). The groups were comparable in terms of demographic data, preoperative American Society of Anesthesiologists grade and extent of liver resection. Intraoperative morbidity and postoperative outcomes were also similar. ALT levels on the day after operation were not decreased by IPC (mean(s.d.) 537\u00b76(358\u00b75) versus 525\u00b70(400\u00b76) units\/ml in IPC and control group respectively; P = 0\u00b7881). Liver biochemistry tests in the week after operation showed the same pattern in both groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>IPC did not reduce liver damage in patients undergoing major liver resection with IPTC. Registration number: NCT00908245 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.7626","type":"journal-article","created":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T11:27:15Z","timestamp":1310383635000},"page":"1236-1243","source":"Crossref","is-referenced-by-count":52,"title":["Randomized clinical trial of ischaemic preconditioning in major liver resection with intermittent Pringle manoeuvre"],"prefix":"10.1093","volume":"98","author":[{"given":"O","family":"Scatton","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Liver Transplantation, H\u00f4pital Cochin, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), France"},{"name":"Universit\u00e9 Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Zalinski","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Liver Transplantation, H\u00f4pital Cochin, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), France"},{"name":"Universit\u00e9 Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Jegou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, H\u00f4pital Cochin, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Compagnon","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Liver Transplantation, H\u00f4pital Pontchaillou, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lesurtel","sequence":"additional","affiliation":[{"name":"Swiss Hepato-Pancreatico-Biliary Centre, Department of Surgery, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Belghiti","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Liver Transplantation, H\u00f4pital Beaujon, AP-HP, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Boudjema","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Liver Transplantation, H\u00f4pital Pontchaillou, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lentschener","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care, H\u00f4pital Cochin, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Soubrane","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Liver Transplantation, H\u00f4pital Cochin, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), France"},{"name":"Universit\u00e9 Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,11]]},"reference":[{"key":"2021070906593740700_bib1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/01.SLA.0000072371.95588.DA","article-title":"Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases","volume":"237","author":"Kooby","year":"2003","journal-title":"Ann Surg"},{"key":"2021070906593740700_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/bjs.6358","article-title":"Impact of postoperative complications on long-term outcome of curative resection for hepatocellular carcinoma","volume":"96","author":"Chok","year":"2009","journal-title":"Br J Surg"},{"key":"2021070906593740700_bib3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jamcollsurg.2004.06.013","article-title":"Major liver resection without clamping: a prospective reappraisal in the era of modern surgical tools","volume":"199","author":"Scatton","year":"2004","journal-title":"J Am Coll Surg"},{"key":"2021070906593740700_bib4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00000658-190810000-00005","article-title":"V. 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