{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:51:17Z","timestamp":1791057077157,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T00:00:00Z","timestamp":1310428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This randomized clinical trial analysed the effect of perioperative selective decontamination of the digestive tract (SDD) in elective gastrointestinal surgery on postoperative infectious complications and leakage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients undergoing elective gastrointestinal surgery during a 5-year period were evaluated for inclusion. Randomized patients received either SDD (polymyxin B sulphate, tobramycin and amphotericin) or placebo in addition to standard antibiotic prophylaxis. The primary endpoint was postoperative infectious complications and anastomotic leakage during the hospital stay or 30 days after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 289 patients were randomized to either SDD (143) or placebo (146). Most patients (190, 65\u00b77 per cent) underwent colonic surgery. There were 28 patients (19\u00b76 per cent) with infectious complications in the SDD group compared with 45 (30\u00b78 per cent) in the placebo group (P = 0\u00b7028). The incidence of anastomotic leakage in the SDD group was 6\u00b73 per cent versus 15\u00b71 per cent in the placebo group (P = 0\u00b7016). Hospital stay and mortality did not differ between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Perioperative SDD in elective gastrointestinal surgery combined with standard intravenous antibiotics reduced the rate of postoperative infectious complications and anastomotic leakage compared with standard intravenous antibiotics alone. Perioperative SD.D should be considered for patients undergoing gastrointestinal surgery. Registration number: P02.1187L (Dutch Central Committee on Research Involving Human Subjects).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.7631","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T13:47:59Z","timestamp":1310478479000},"page":"1365-1372","source":"Crossref","is-referenced-by-count":49,"title":["Randomized clinical trial of perioperative selective decontamination of the digestive tract <i>versus<\/i> placebo in elective gastrointestinal surgery"],"prefix":"10.1093","volume":"98","author":[{"given":"D","family":"Roos","sequence":"first","affiliation":[{"name":"Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Dijksman","sequence":"additional","affiliation":[{"name":"Teaching Hospital, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Oudemans-van Straaten","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L T","family":"de Wit","sequence":"additional","affiliation":[{"name":"Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Gouma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Gerhards","sequence":"additional","affiliation":[{"name":"Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,12]]},"reference":[{"key":"2021070906411982700_bib1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1086\/501572","article-title":"The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs","volume":"20","author":"Kirkland","year":"1999","journal-title":"Infect Control Hosp Epidemiol"},{"key":"2021070906411982700_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/jinf.2002.1073","article-title":"Nosocomial infection and related risk factors in a general surgery service: a prospective study","volume":"46","author":"Vazquez-Aragon","year":"2003","journal-title":"J Infect"},{"key":"2021070906411982700_bib3","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1086\/501620","article-title":"Guideline for prevention of surgical site infection, 1999. 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