{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:56:13Z","timestamp":1791024973039,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T00:00:00Z","timestamp":1317340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conventional laparoscopy with three or more ports remains the \u2018gold standard\u2019 for cholecystectomy, but a laparoendoscopic single-site (LESS) approach is emerging, designed to decrease parietal trauma and improve cosmesis. This study compared conventional laparoscopic (CL) with LESS cholecystectomy, with short-term clinical results as the main outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized trial of CL and LESS cholecystectomies involving 150 patients was undertaken. Follow-up was for 1 month after surgery. The primary endpoint was body image results evaluated by means of validated scales. Secondary endpoints were: postoperative pain measured on a visual analogue scale, analgesia requirement, morbidity, quality of life (QoL) measured with Short Form 12, duration of operation, hospital stay, time to return to work and cost analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Operating times and complications were similar in the two groups. Two LESS procedures (3 per cent) were converted to two-port laparoscopy owing to difficulties with exposure, and one CL operation was achieved through a single port because extensive fibrous peritoneal adhesions prevented placement of other ports. There were three and four port-site seroma\/haematomas in the LESS and CL groups respectively. Better pain profiles and lower analgesia requirements were recorded in the LESS group (P &amp;lt; 0\u00b7001). QoL, body image and scar scale results were also better (P &amp;lt; 0\u00b7001). Operative costs were higher for LESS procedures (P &amp;lt; 0\u00b7001), although median time to return to work was shorter (P = 0\u00b7003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LESS is an alternative to CL cholecystectomy associated with better cosmesis, body image, QoL and an improved postoperative pain profile. Registration number: NCT00904865 (http:\/\/www.clinicaltrials.gov).<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.7689","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T16:42:37Z","timestamp":1317400957000},"page":"1695-1702","source":"Crossref","is-referenced-by-count":159,"title":["Randomized clinical trial of laparoendoscopic single-site<i>versus<\/i>conventional laparoscopic cholecystectomy"],"prefix":"10.1093","volume":"98","author":[{"given":"P","family":"Bucher","sequence":"first","affiliation":[{"name":"Department of Surgery, University Hospital Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pugin","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N C","family":"Buchs","sequence":"additional","affiliation":[{"name":"Department of Surgery, University 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