{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:14:43Z","timestamp":1773029683215,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Weight loss following obesity surgery is associated with gallstone formation, but there is limited evidence on whether prophylactic cholecystectomy is indicated during obesity surgery. The aim of this study was to clarify the need for cholecystectomy following obesity surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A Swedish nationwide, population-based cohort study was conducted during the 22-year interval 1987\u20132008. Need for later cholecystectomy for gallstone disease was assessed in patients who had undergone obesity surgery in comparison with the general population of corresponding age, sex and calendar year. This need was also compared with the need for cholecystectomy in cohorts of patients who had undergone antireflux surgery and appendicectomy. Standardized incidence ratios (SIRs) with 95 per cent confidence intervals (c.i.) were calculated to estimate the relative risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the obesity surgery cohort of 13 443 patients, the observed number of cholecystectomies (1149, 8\u00b75 per cent) exceeded the expected number by over fivefold (SIR 5\u00b75, 95 per cent c.i. 5\u00b71 to 5\u00b78). The observed need for imperative cholecystectomy (for cholecystitis, cholangitis, pancreatitis, or jaundice; 427, 3\u00b72 per cent) was also greater than expected (SIR 5\u00b72, 4\u00b77 to 5\u00b77). The SIR peaked 7\u201324 months after obesity surgery and decreased with longer follow-up. The SIRs for cholecystectomy after antireflux surgery and appendicectomy were 2\u00b74 (2\u00b72 to 2\u00b76) and 1\u00b77 (1\u00b76 to 1\u00b77) respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An increased need for cholecystectomy after obesity surgery was confirmed, but was probably partly due to an increased detection of gallbladder disease only because of the surgery; the individual's risk of imperative cholecystectomy was low. Therefore, prophylactic cholecystectomy might not be recommended during obesity surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.8701","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T13:07:30Z","timestamp":1331125650000},"page":"864-869","source":"Crossref","is-referenced-by-count":41,"title":["Population-based study of the need for cholecystectomy after obesity surgery"],"prefix":"10.1093","volume":"99","author":[{"given":"M","family":"Plecka \u00d6stlund","sequence":"first","affiliation":[{"name":"Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Wenger","sequence":"additional","affiliation":[{"name":"Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"National Board of Health and Welfare, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Botha","sequence":"additional","affiliation":[{"name":"Department of General Surgery, St Thomas' Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Lagergren","sequence":"additional","affiliation":[{"name":"Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"},{"name":"Division of Cancer Studies, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"key":"2021031605233919200_bib1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1056\/NEJM199910073411501","article-title":"Body-mass index and mortality in a prospective cohort of U.S. adults","volume":"341","author":"Calle","year":"1999","journal-title":"N Engl J Med"},{"key":"2021031605233919200_bib2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1056\/NEJMoa066254","article-title":"Effects of bariatric surgery on mortality in Swedish obese subjects","volume":"357","author":"Sj\u00f6str\u00f6m","year":"2007","journal-title":"N Engl J Med"},{"key":"2021031605233919200_bib3","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1007\/s00464-008-0204-6","article-title":"Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy","volume":"23","author":"Li","year":"2009","journal-title":"Surg Endosc"},{"key":"2021031605233919200_bib4","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/00042737-200012120-00015","article-title":"Gallstones in obesity and weight loss","volume":"12","author":"Erlinger","year":"2000","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2021031605233919200_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.soard.2007.02.006","article-title":"Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass","volume":"3","author":"Portenier","year":"2007","journal-title":"Surg Obes Relat Dis"},{"key":"2021031605233919200_bib6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.soard.2007.05.007","article-title":"Routine cholecystectomy during laparoscopic biliopancreatic diversion with duodenal switch is not necessary","volume":"3","author":"Bardaro","year":"2007","journal-title":"Surg Obes Relat Dis"},{"key":"2021031605233919200_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11695-007-9368-8","article-title":"Almost routine prophylactic cholecystectomy during laparoscopic gastric bypass is safe","volume":"18","author":"Nougou","year":"2008","journal-title":"Obes Surg"},{"key":"2021031605233919200_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11695-007-9262-4","article-title":"Routine preoperative ultrasonography and selective cholecystectomy in laparoscopic Roux-en-Y gastric bypass. 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