{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:54:29Z","timestamp":1791147269714,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T00:00:00Z","timestamp":1349222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Re-use of this article is permitted in accordance with the Terms and Conditions set out at [http:\/\/wileyonlinelibrary.com\/onlineopen#OnlineOpen_Terms]"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The long-term effects of abdominal aortic aneurysm (AAA) screening were investigated in extended follow-up from the UK Multicentre Aneurysm Screening Study (MASS) randomized trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A population-based sample of men aged 65\u201374 years were randomized individually to invitation to ultrasound screening (invited group) or to a control group not offered screening. Patients with an AAA (3\u00b70 cm or larger) detected at screening underwent surveillance and were offered surgery after predefined criteria had been met. Cause-specific mortality data were analysed using Cox regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 67 770 men were enrolled in the study. Over 13 years, there were 224 AAA-related deaths in the invited group and 381 in the control group, a 42 (95 per cent confidence interval 31 to 51) per cent reduction. There was no evidence of effect on other causes of death, but there was an overall reduction in all-cause mortality of 3 (1 to 5) per cent. The degree of benefit seen in earlier years of follow-up was slightly diminished by the occurrence of AAA ruptures in those with an aorta originally screened normal. About half of these ruptures had a baseline aortic diameter in the range 2\u00b75\u20132\u00b79 cm. It was estimated that 216 men need to be invited to screening to save one death over the next 13 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Screening resulted in a reduction in all-cause mortality, and the benefit in AAA-related mortality continued to accumulate throughout follow-up. Registration number: ISRCTN37381646 (http:\/\/www.controlled-trials.com).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.8897","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T15:39:36Z","timestamp":1349278776000},"page":"1649-1656","source":"Crossref","is-referenced-by-count":241,"title":["Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening"],"prefix":"10.1093","volume":"99","author":[{"given":"S G","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Ashton","sequence":"additional","affiliation":[{"name":"Sussex Community NHS Trust, St Richard's Hospital, Chichester, UK"},{"name":"Western Sussex Hospitals NHS Trust, St Richard's Hospital, Chichester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical Research Council Biostatistics Unit, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Buxton","sequence":"additional","affiliation":[{"name":"Health Economics Research Group, Brunel University, Uxbridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A P","family":"Scott","sequence":"additional","affiliation":[{"name":"Western Sussex Hospitals NHS Trust, St Richard's Hospital, Chichester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,3]]},"reference":[{"key":"2021031606554369700_bib1","volume-title":"NHS Abdominal Aortic Aneurysm (AAA) Screening Programme: Annual Report 2010\u201311"},{"key":"2021031606554369700_bib2","volume-title":"Scottish Abdominal Aortic Aneurysm Screening 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