{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:55:23Z","timestamp":1778158523232,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T00:00:00Z","timestamp":1352160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Major surgery for cancer has become safer, including for elderly patients with co-morbidity. The aim of this study was to investigate the association between patient characteristics, resection rates and survival among patients with oesophageal or gastric cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The prospective Dutch population-based Eindhoven Cancer Registry for oesophagogastric cancers diagnosed between 1995 and 2009 was studied retrospectively for patient characteristics including co-morbidity. Logistic regression analysis was performed to assess the likelihood of resection in patients with tumour node metastasis (TNM) stage I\u2013III lesions. Cox proportional hazard analysis was used to estimate hazard ratios (HRs) for survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The database contained information on 923 patients with oesophageal squamous cell carcinoma, 1181 with distal oesophageal, 942 with cardia and 3177 with subcardia cancer. Of patients with TNM stage I\u2013III disease, 20\u00b78 per cent (557 of 2680 patients) did not undergo resection. Age 70 years or above was associated with a lower likelihood of resection for distal oesophageal (odds ratio (OR) 0\u00b724, 95 per cent confidence interval (c.i.) 0\u00b714 to 0\u00b741) and gastric (cardia: OR 0\u00b741, 0\u00b722 to 0\u00b776; subcardia: OR 0\u00b768, 0\u00b748 to 0\u00b797) cancer. The 30-day mortality rate increased with age (4\u00b77 per cent in patients aged less than 70 years versus 11\u00b79 per cent in those aged 70 years or more; P &amp;lt; 0\u00b7001) and co-morbidity (no co-morbidity, 3\u00b76 per cent; 1 co-morbidity, 8\u00b76 per cent; 2 or more co-morbidities, 11\u00b72 per cent; P = 0\u00b7015). Surgery (compared with no surgery) was independently associated with better survival for all tumour types. After adjustment for treatment differences, age 70 years or above and presence of two or more co-morbidities were independently associated with poorer survival, especially in patients with subcardia carcinoma (age 70 years or more: HR 1\u00b727, 95 per cent c.i. 1\u00b717 to 1\u00b748; co-morbidity: HR 1\u00b733, 1\u00b721 to 1\u00b762).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Surgical compared with non-surgical treatment of oesophagogastric cancer was associated with better survival, but postoperative mortality was increased in patients of advanced age and with greater co-morbidity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.8952","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T13:47:25Z","timestamp":1352209645000},"page":"1693-1700","source":"Crossref","is-referenced-by-count":64,"title":["Impact of age and co-morbidity on surgical resection rate and survival in patients with oesophageal and gastric cancer"],"prefix":"10.1093","volume":"99","author":[{"given":"L B","family":"Koppert","sequence":"first","affiliation":[{"name":"Department of Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V E P P","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus Medical Centre, Rotterdam, The Netherlands"},{"name":"Department of Research, Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J W W","family":"Coebergh","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus Medical Centre, Rotterdam, The Netherlands"},{"name":"Department of Research, Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E W","family":"Steyerberg","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B P L","family":"Wijnhoven","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H W","family":"Tilanus","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L G","family":"Janssen-Heijnen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, VieCuri Medical Centre, Venlo, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,6]]},"reference":[{"key":"2021031607094982000_bib1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.ejca.2012.01.009","article-title":"Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands","volume":"48","author":"Dikken","year":"2012","journal-title":"Eur J Cancer"},{"key":"2021031607094982000_bib2","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMra035010","article-title":"Esophageal cancer","volume":"349","author":"Enzinger","year":"2003","journal-title":"N Engl J Med"},{"key":"2021031607094982000_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00042737-200403000-00003","article-title":"Systemic treatment of gastric cancer","volume":"16","author":"Dickson","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2021031607094982000_bib4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1365-2168.1999.01082.x","article-title":"Adenocarcinomas of the distal oesophagus and gastric cardia are one clinical entity. 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