{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:56:04Z","timestamp":1791024964422,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This three-armed randomized clinical trial, with blinding of patients and outcome assessors, tested the hypothesis that single-port (SP) and\/or minilaparoscopic (ML) cholecystectomy are superior to conventional laparoscopic (CL) cholecystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients eligible for elective laparoscopic cholecystectomy were randomized to SP, ML or CL procedures. The primary outcome was pain measured on a visual analogue scale twice daily during the blinded period. Secondary outcomes included duration of operation, technical performance score, complications, quality of life, cosmesis and patient satisfaction. Postoperative follow-up lasted 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 105 patients were randomized, 35 in each group. One conversion from a SP to a CL technique was necessary in a patient with chronic cholecystitis. Pain intensity was similar in the three groups, both during the blinded period (day 0 to 3; P = 0\u00b7865) and over the whole 7-day evaluation period (P = 0\u00b7911). The presence of clinically relevant between-group differences was ruled out (95 per cent confidence interval + 1\u00b70 to \u2212 0\u00b75 for difference in pain scores between SP and CL groups, and \u2212 0\u00b78 to + 0\u00b76 between ML and CL groups). Operating time was significantly longer for SP and ML than for CL cholecystectomy (P = 0\u00b7001). Postoperative complications included injury to the diaphragm (1), choledocholithiasis (1), wound infection (5) and hernia (1), all after SP cholecystectomy (P = 0\u00b7001). Twelve-month follow-up was complete in 99 patients (94\u00b73 per cent). Cosmesis as rated by patients was significantly better at 6 months after SP and ML procedures (P = 0\u00b7043), but no difference was observed at 12 months (P = 0\u00b7229).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SP and ML cholecystectomy had no advantage over the CL approach in terms of postoperative outcome. Registration number: DRKS00000302 (German Registry of Clinical Trials).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.9003","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T17:18:16Z","timestamp":1354036696000},"page":"339-349","source":"Crossref","is-referenced-by-count":92,"title":["Randomized clinical trial of single-port, minilaparoscopic and conventional laparoscopic cholecystectomy"],"prefix":"10.1093","volume":"100","author":[{"given":"S","family":"Saad","sequence":"first","affiliation":[{"name":"Department of General Surgery, Clinic Gummersbach, Academic Hospital University Cologne , Gummersbach,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Strassel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Clinic Gummersbach, Academic Hospital University Cologne , Gummersbach,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sauerland","sequence":"additional","affiliation":[{"name":"Institute for Research in Operative Medicine, University of Witten\/Herdecke , Cologne,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2024092904584031600_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/bmj.322.7278.91","article-title":"ABC of diseases of liver, pancreas, and biliary system. 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