{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:30:23Z","timestamp":1790307023507,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Benign strictures at the cardia are troublesome for patients and often require repeated endoscopic treatments. Paclitaxel can reduce fibrosis. This study evaluated a biodegradable paclitaxel-eluting nanofibre-covered metal stent for the treatment of benign cardia stricture in vitro and in vivo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Drug release was investigated in vitro at pH 7\u00b74 and 4\u00b70. Eighty dogs were divided randomly into four groups (each n = 20): controls (no stent), bare stent (retained for 1 week), and two drug-eluting stent (DES) groups with retention for either 1 week (DES-1w) or 4 weeks (DES-4w). Lower oesophageal sphincter pressure (LOSP) and 5-min barium height (5-mBH) were assessed before, immediately after stent deployment, at 1 week, and 1, 3 and 6 months later. Five dogs in each group were killed for histological examination at each follow-up point.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Stent migration rates were similar (0 bare stent versus 2 DES; P = 0\u00b7548). The percentage and amount of paclitaxel released in vitro was higher at pH 4\u00b70 than at pH 7\u00b74. After 6 months, LOSP and 5-mBH were both improved in the DES-1w (P = 0\u00b7004 and P = 0\u00b7049) and DES-4w (both P &amp;lt; 0\u00b7001) groups compared with the bare-stent group, with better relief when the stent was retained for 4 weeks (P = 0\u00b7004 and P = 0\u00b7007). The DES was associated with a reduced peak inflammatory reaction and less scar formation compared with bare stents, especially when inserted for 4 weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The DES was more effective for the treatment of benign cardia stricture than bare stents in a canine model. Retention of the DES for 4 weeks led to a better clinical and pathological outcome than 1 week.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9106","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T09:29:55Z","timestamp":1364894995000},"page":"784-793","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of biodegradable paclitaxel-eluting nanofibre-covered metal stents for the treatment of benign cardia stricture in an experimental model"],"prefix":"10.1093","volume":"100","author":[{"given":"Y-Q","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiology, Sixth Affiliated People's Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W-G","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 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