{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:13:14Z","timestamp":1789603994223,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The most common indications for surgery for patients with ileocolic Crohn's disease are fibrostenotic or perforating disease. The objective was to compare surgical outcomes of patients with perforating versus non-perforating disease following ileocolic resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective review of all patients who had their first ileocolic resection between 1990 and 2010, identified from a prospectively maintained inflammatory bowel disease database. Demographic information, preoperative medication, intraoperative findings and postoperative outcome data were collected. Outcomes in patients who had an abscess drained before surgery or were found to have a fistula or abscess at surgery or at pathology were compared with outcomes in all others.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 434 patients (56\u00b72 per cent women) were included, 293 with perforating and 141 with non-perforating disease. Median age, tobacco use, and preoperative steroid and biological agent use were similar in the two groups. Forty patients (13\u00b77 per cent) in the perforating group had abscesses drained before surgery and 251 patients had at least one fistula, most commonly to the sigmoid colon. Patients with perforating disease were more likely to require preoperative total parenteral nutrition, need another resection, have an ileostomy and a longer mean postoperative stay, and less likely to undergo a laparoscopic procedure. Patients in this group also developed more postoperative abscesses or leaks (4\u00b78 versus 0 per cent; P = 0\u00b7006). The reoperation rate was similar (3\u00b71 versus 0\u00b77 per cent; P = 0\u00b7178).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with penetrating Crohn's disease are more likely to require a more complex procedure, and an ileostomy, and to a have longer postoperative stay.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9212","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T13:20:05Z","timestamp":1381843205000},"page":"1344-1348","source":"Crossref","is-referenced-by-count":40,"title":["Outcomes following surgery for perforating Crohn's disease"],"prefix":"10.1093","volume":"100","author":[{"given":"F","family":"Bellolio","sequence":"first","affiliation":[{"name":"Division of General Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Zane Cohen Centre for Digestive Diseases, University of Toronto, Toronto, Ontario, Canada"},{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of General Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Zane Cohen Centre for Digestive Diseases, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"MacRae","sequence":"additional","affiliation":[{"name":"Division of General Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B I","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Division of General Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Zane Cohen Centre for Digestive Diseases, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Huang","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Victor","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"McLeod","sequence":"additional","affiliation":[{"name":"Division of General Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Zane Cohen Centre for Digestive Diseases, University of Toronto, Toronto, Ontario, Canada"},{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,8,12]]},"reference":[{"key":"2021031208425688100_bjs9212-bib-0001","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can J Gastroenterol"},{"key":"2021031208425688100_bjs9212-bib-0002","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0016-5085(98)70191-X","article-title":"Risk factors for early postoperative recurrence of Crohn's disease","volume":"115","author":"Lautenbach","year":"1998","journal-title":"Gastroenterology"},{"key":"2021031208425688100_bjs9212-bib-0003","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000089960","article-title":"Risk factors regarding the need for a second operation in patients with Crohn's disease","volume":"72","author":"Avidan","year":"2005","journal-title":"Digestion"},{"key":"2021031208425688100_bjs9212-bib-0004","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s003840050065","article-title":"Factors affecting recurrence in Crohn's disease. Results of a prospective audit","volume":"11","author":"Poggioli","year":"1996","journal-title":"Int J Colorectal Dis"},{"key":"2021031208425688100_bjs9212-bib-0005","first-page":"601","article-title":"Comparison of long-term course of perforating and non-perforating Crohn's disease","volume":"22","author":"Hamon","year":"1998","journal-title":"Gastroenterol Clin Biol"},{"key":"2021031208425688100_bjs9212-bib-0006","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF02234180","article-title":"Perforating ileocecal Crohn's disease does not carry a high risk of recurrence but usually re-presents as perforating disease","volume":"42","author":"Yamamoto","year":"1999","journal-title":"Dis Colon Rectum"},{"key":"2021031208425688100_bjs9212-bib-0007","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1572-0241.2007.01548.x","article-title":"A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn's disease","volume":"103","author":"Simillis","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"2021031208425688100_bjs9212-bib-0008","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/BF02236563","article-title":"Risk factors for intra-abdominal sepsis after surgery in Crohn's disease","volume":"43","author":"Yamamoto","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"2021031208425688100_bjs9212-bib-0009","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10350-006-0782-0","article-title":"Risk factors for intra-abdominal septic complications alter a first ileocolic resection for Crohn's disease: a multivariate analysis in 161 consecutive patients","volume":"50","author":"Alves","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"2021031208425688100_bjs9212-bib-0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2036.2010.04369.x","article-title":"Pre-operative management is associated with low rate of post-operative morbidity in penetrating Crohn's disease","volume":"32","author":"Zerbib","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"2021031208425688100_bjs9212-bib-0011","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1572-0241.2007.01548.x","article-title":"A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn's disease","volume":"103","author":"Simillis","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"2021031208425688100_bjs9212-bib-0012","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1007\/s00464-009-0362-1","article-title":"Laparoscopic resection for Crohn's disease: an experience with 335 cases","volume":"23","author":"Nguyen","year":"2009","journal-title":"Surg Endosc"},{"key":"2021031208425688100_bjs9212-bib-0013","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s00464-008-0308-z","article-title":"Safety, feasibility, and short-term outcomes of laparoscopically assisted primary ileocolic resection for Crohn's disease","volume":"23","author":"Soop","year":"2009","journal-title":"Surg Endosc"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.9212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/100\/10\/1344\/36579828\/bjs9212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/100\/10\/1344\/36579828\/bjs9212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T14:09:40Z","timestamp":1621519780000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/100\/10\/1344-1348\/6138448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,12]]},"references-count":13,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,8,12]]},"published-print":{"date-parts":[[2013,8,12]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.9212","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,9]]},"published":{"date-parts":[[2013,8,12]]}}}