{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:26:45Z","timestamp":1793320005778,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bowel dysfunction after sphincter-preserving surgery for rectal cancer is a common complication, with the potential to affect quality of life (QoL) strongly. The aim of this study was to examine the extent of bowel dysfunction and impact on health-related QoL after curative sphincter-preserving resection for rectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>QoL was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire, and bowel function using a validated questionnaire, including the recently developed low anterior resection syndrome (LARS) score. Assessments were carried out at the time of diagnosis, and at 3 and 12 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 260 patients were included in the study. At 3 months, 58\u00b70 per cent of patients had a LARS score of 30 or more (major LARS), which declined to 45\u00b79 per cent at 12 months (P &amp;lt; 0\u00b7001). The risk of major LARS was significantly increased in patients who received neoadjuvant therapy (odds ratio 2\u00b741, 95 per cent confidence interval 1\u00b700 to 5\u00b783), and after total versus partial mesorectal excision (odds ratio 2\u00b781, 1\u00b735 to 5\u00b788). Global health status was closely associated with LARS, and significant differences in global health status, functional and symptom scales of QoL were found between patients without LARS and those with major LARS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bowel dysfunction is a major problem with an immense impact on QoL following sphincter-preserving resection. The risk of major LARS was significantly increased after neoadjuvant therapy and total mesorectal excision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.9223","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T09:20:05Z","timestamp":1381828805000},"page":"1377-1387","source":"Crossref","is-referenced-by-count":392,"title":["Impact of bowel dysfunction on quality of life after sphincter-preserving resection for rectal cancer"],"prefix":"10.1093","volume":"100","author":[{"given":"K J","family":"Emmertsen","sequence":"first","affiliation":[{"name":"Colorectal Research Unit, Colorectal Surgical Department P, Aarhus University Hospital Tage-Hansens Gade 2 DK-8000, Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Laurberg","sequence":"additional","affiliation":[{"name":"Colorectal Research Unit, Colorectal Surgical Department P, Aarhus University Hospital Tage-Hansens Gade 2 DK-8000, Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Jess","sequence":"additional","affiliation":[{"name":"Surgical Department, Hilleroed Hospital, Hilleroed, Denmark"},{"name":"Faculty of Health, Copenhagen University, Copenhagen, Denmark"},{"name":"Department of Surgery, Roskilde Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herning Regional Hospital, Herning, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H J","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Surgical Section, The Gastro-unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A U","family":"Ovesen","sequence":"additional","affiliation":[{"name":"Department of Surgery A, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Salomon","sequence":"additional","affiliation":[{"name":"Surgical Department A, Odense University Hospital Svendborg, Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Thygesen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Surgery K, Regional Hospital Randers, Randers, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Vilandt","sequence":"additional","affiliation":[{"name":"Surgical Department, Hilleroed Hospital, Hilleroed, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,8,12]]},"reference":[{"key":"2021031208425029900_bjs9223-bib-0001","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1098-2388(200004\/05)18:3<249::AID-SSU9>3.0.CO;2-P","article-title":"Surgical approaches to obtaining optimal bowel function","volume":"18","author":"Hallb\u00f6\u00f6k","year":"2000","journal-title":"Semin Surg Oncol"},{"key":"2021031208425029900_bjs9223-bib-0002","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/01.sla.0000080823.38569.b0","article-title":"Quality of life in rectal cancer patients: a four-year prospective study","volume":"238","author":"Engel","year":"2003","journal-title":"Ann Surg"},{"key":"2021031208425029900_bjs9223-bib-0003","article-title":"International validation of the low anterior resection syndrome score","author":"Juul","year":"2013","journal-title":"Ann Surg"},{"key":"2021031208425029900_bjs9223-bib-0004","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/SLA.0b013e31824f1c21","article-title":"Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer","volume":"255","author":"Emmertsen","year":"2012","journal-title":"Ann Surg"},{"key":"2021031208425029900_bjs9223-bib-0005","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00066-005-1313-y","article-title":"Dose\u2013response relations for anal sphincter regarding fecal leakage and blood or phlegm in stools after radiotherapy for prostate cancer. 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