{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:28Z","timestamp":1786977388205,"version":"build-2736575974"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite advances in medical therapy, there remains no effective preventive or non-surgical therapeutic option for fibrostenotic Crohn's disease (CD). Symptomatic recurrences are common, necessitating reintervention. Intestinal fibroblasts mediate stricture formation, but their exact source is unclear. Recent evidence indicates that circulating fibrocytes drive fibrosis through differentiation into fibroblasts and the production of extracellular matrix proteins. The aim of this review is to describe current understanding of the pathophysiology underlying fibrosis in CD, the cellular and molecular biology of fibrocytes and their role in CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The electronic literature (January 1972 to December 2012) on \u2018circulating fibrocytes\u2019 and \u2018Crohn's fibrosis\u2019 was reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Circulating fibrocytes appear universally involved in organ fibrosis. A complex array of cytokines, chemokines and growth factors regulate fibrocyte biology, and these are associated with fibrogenesis in CD. The cytokines transforming growth factor \u03b21, connective tissue growth factor and interleukin 13, overexpressed in the strictured Crohn's intestine, promote fibrocyte generation and\/or differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Levels of circulating fibrocytes are raised in conditions marked by exaggerated fibrosis. These and other observations prompt a characterization of fibrocyte activity in CD with a view to investigating a pathogenic role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.9302","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T06:45:21Z","timestamp":1402296321000},"page":"1549-1556","source":"Crossref","is-referenced-by-count":34,"title":["Circulating fibrocytes and Crohn's disease"],"prefix":"10.1093","volume":"100","author":[{"given":"S M","family":"Sahebally","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Limerick, Ireland"},{"name":"4i Centre for Interventions In Inflammation, Infection and Immunity, Graduate Entry Medical School, University of Limerick, Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K H","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Kiernan","sequence":"additional","affiliation":[{"name":"4i Centre for Interventions In Inflammation, Infection and Immunity, Graduate Entry Medical School, University of Limerick, Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P R","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland"},{"name":"School of Medicine and Medical Science, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Limerick, Ireland"},{"name":"4i Centre for Interventions In Inflammation, Infection and Immunity, Graduate Entry Medical School, University of Limerick, Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"2021031607395378300_bjs9302-bib-0001","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0140-6736(12)60026-9","article-title":"Crohn's disease","volume":"380","author":"Baumgart","year":"2012","journal-title":"Lancet"},{"key":"2021031607395378300_bjs9302-bib-0002","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/ibd.21695","article-title":"Increasing incidence of inflammatory bowel diseases between 2000 and 2007: a nationwide register study in Finland","volume":"18","author":"Jussila","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"2021031607395378300_bjs9302-bib-0003","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1572-0241.2006.01010.x","article-title":"Fibrogenesis in Crohn's disease","volume":"102","author":"Burke","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"2021031607395378300_bjs9302-bib-0004","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00054725-200401000-00009","article-title":"Medical therapy for Crohn's disease strictures","volume":"10","author":"Van Assche","year":"2004","journal-title":"Inflamm Bowel Dis"},{"key":"2021031607395378300_bjs9302-bib-0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00000658-200001000-00006","article-title":"Risk factors for surgery and postoperative recurrence in Crohn's disease","volume":"231","author":"Bernell","year":"2000","journal-title":"Ann Surg"},{"key":"2021031607395378300_bjs9302-bib-0006","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/145749691009900405","article-title":"The role of surgery in Crohn's disease: a retrospective analysis from a single hospital","volume":"99","author":"Aarnio","year":"2010","journal-title":"Scand J Surg"},{"key":"2021031607395378300_bjs9302-bib-0007","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1072-7515(01)00775-X","article-title":"Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn's disease","volume":"192","author":"Dietz","year":"2001","journal-title":"J Am Coll Surg"},{"key":"2021031607395378300_bjs9302-bib-0008","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/0016-5085(90)90613-6","article-title":"Predictability of the postoperative course of Crohn's disease","volume":"99","author":"Rutgeerts","year":"1990","journal-title":"Gastroenterology"},{"key":"2021031607395378300_bjs9302-bib-0009","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/SLA.0b013e3181e61df5","article-title":"Trends in surgery for Crohn's disease in the era of infliximab","volume":"252","author":"Jones","year":"2010","journal-title":"Ann Surg"},{"key":"2021031607395378300_bjs9302-bib-0010","doi-asserted-by":"crossref","DOI":"10.1007\/s00384-013-1698-5","article-title":"National trends in intestinal resection for Crohn's disease in the post-biologic era","author":"Burke","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"2021031607395378300_bjs9302-bib-0011","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1053\/j.gastro.2008.09.012","article-title":"Direct health care costs of Crohn's disease and ulcerative colitis in US children and adults","volume":"135","author":"Kappelman","year":"2008","journal-title":"Gastroenterology"},{"key":"2021031607395378300_bjs9302-bib-0012","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0016-5085(88)90411-8","article-title":"Collagen content and types in the intestinal strictures of Crohn's disease","volume":"94","author":"Graham","year":"1988","journal-title":"Gastroenterology"},{"key":"2021031607395378300_bjs9302-bib-0013","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/bjs.4453","article-title":"Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease","volume":"91","author":"Beddy","year":"2004","journal-title":"Br J Surg"},{"key":"2021031607395378300_bjs9302-bib-0014","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00054725-199509000-00008","article-title":"Pathogenesis of intestinal strictures in Crohn's disease\u2014an update","volume":"1","author":"Graham","year":"1995","journal-title":"Inflamm Bowel Dis"},{"key":"2021031607395378300_bjs9302-bib-0015","doi-asserted-by":"crossref","first-page":"G653","DOI":"10.1152\/ajpgi.2000.279.4.G653","article-title":"Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models","volume":"279","author":"Pucilowska","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2021031607395378300_bjs9302-bib-0016","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00000658-200001000-00007","article-title":"Stricture formation in Crohn's disease: the role of intestinal fibroblasts","volume":"231","author":"Regan","year":"2000","journal-title":"Ann Surg"},{"key":"2021031607395378300_bjs9302-bib-0017","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jcp.1041440113","article-title":"Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors","volume":"144","author":"Finesmith","year":"1990","journal-title":"J Cell Physiol"},{"key":"2021031607395378300_bjs9302-bib-0018","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.revmed.2005.10.004","article-title":"Involvement of TGFbeta1 in fibrotic diseases: role of its effectors, the Smad proteins","volume":"27","author":"Dennler","year":"2006","journal-title":"Rev Med Interne"},{"key":"2021031607395378300_bjs9302-bib-0019","doi-asserted-by":"crossref","first-page":"C172","DOI":"10.1152\/ajpcell.00048.2001","article-title":"Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts","volume":"282","author":"McKaig","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"2021031607395378300_bjs9302-bib-0020","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/ibd.20482","article-title":"Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease","volume":"14","author":"Burke","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2021031607395378300_bjs9302-bib-0021","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/gut.2008.149096","article-title":"Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures","volume":"58","author":"Di Sabatino","year":"2009","journal-title":"Gut"},{"key":"2021031607395378300_bjs9302-bib-0022","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1172\/JCI13863","article-title":"TGF-beta\/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation","volume":"108","author":"Fiocchi","year":"2001","journal-title":"J Clin Invest"},{"key":"2021031607395378300_bjs9302-bib-0023","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ajpath.2012.11.014","article-title":"Regulation and role of connective tissue growth gactor in AngII-induced myocardial fibrosis","volume":"182","author":"Rosin","year":"2013","journal-title":"Am J Pathol"},{"key":"2021031607395378300_bjs9302-bib-0024","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/01.sla.0000189606.58343.cd","article-title":"Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1\/2 mitogen activated protein kinase cell signaling","volume":"242","author":"Mulsow","year":"2005","journal-title":"Ann Surg"},{"key":"2021031607395378300_bjs9302-bib-0025","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/bjs.5431","article-title":"Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease","volume":"93","author":"Beddy","year":"2006","journal-title":"Br J Surg"},{"key":"2021031607395378300_bjs9302-bib-0026","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/bjs.6577","article-title":"Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor \u03b21-mediated activation of intestinal fibroblasts","volume":"96","author":"Burke","year":"2009","journal-title":"Br J Surg"},{"key":"2021031607395378300_bjs9302-bib-0027","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1161\/CIRCULATIONAHA.111.080002","article-title":"Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure","volume":"125","author":"Kapur","year":"2012","journal-title":"Circulation"},{"key":"2021031607395378300_bjs9302-bib-0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12079-011-0154-y","article-title":"Endoglin in liver fibrosis","volume":"6","author":"Finnson","year":"2012","journal-title":"J Cell Commun Signal"},{"key":"2021031607395378300_bjs9302-bib-0029","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/ndt\/gfl179","article-title":"Endoglin regulates renal ischaemia\u2013reperfusion injury","volume":"21","author":"Docherty","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"2021031607395378300_bjs9302-bib-0030","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/bjs.6996","article-title":"Endoglin negatively regulates transforming growth factor \u03b21-induced profibrotic responses in intestinal fibroblasts","volume":"97","author":"Burke","year":"2010","journal-title":"Br J Surg"},{"key":"2021031607395378300_bjs9302-bib-0031","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J"},{"key":"2021031607395378300_bjs9302-bib-0032","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0898-6568(02)00058-X","article-title":"Integration of the TGF-beta pathway into the cellular signalling network","volume":"14","author":"Lutz","year":"2002","journal-title":"Cell Signal"},{"key":"2021031607395378300_bjs9302-bib-0033","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000117306","article-title":"Role of biologics and other therapies in stricturing Crohn's disease: what have we learnt so far?","volume":"77","author":"Sorrentino","year":"2008","journal-title":"Digestion"},{"key":"2021031607395378300_bjs9302-bib-0034","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00384-005-0739-0","article-title":"Selective effect of infliximab on the inflammatory component of a colonic stricture in Crohn's disease","volume":"21","author":"Sorrentino","year":"2006","journal-title":"Int J Colorectal Dis"},{"key":"2021031607395378300_bjs9302-bib-0035","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3748\/wjg.14.1885","article-title":"Effect of infliximab on small bowel stenoses in patients with Crohn's disease","volume":"14","author":"Pallotta","year":"2008","journal-title":"World J Gastroenterol"},{"key":"2021031607395378300_bjs9302-bib-0036","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2036.2008.03887.x","article-title":"Infliximab treatment for symptomatic Crohn's disease strictures","volume":"29","author":"Pelletier","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"2021031607395378300_bjs9302-bib-0037","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1357-2725(98)00046-6","article-title":"Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?","volume":"30","author":"Dammeier","year":"1998","journal-title":"Int J Biochem Cell Biol"},{"key":"2021031607395378300_bjs9302-bib-0038","doi-asserted-by":"crossref","first-page":"G1307","DOI":"10.1152\/ajpgi.2000.279.6.G1307","article-title":"IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease","volume":"279","author":"Pucilowska","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2021031607395378300_bjs9302-bib-0039","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"Phillips","year":"2004","journal-title":"J Clin Invest"},{"key":"2021031607395378300_bjs9302-bib-0040","doi-asserted-by":"crossref","first-page":"14 098","DOI":"10.1073\/pnas.0511200103","article-title":"Secondary lymphoid tissue chemokine (SLC\/CCL21)\/CCR7 signaling regulates fibrocytes in renal fibrosis","volume":"103","author":"Sakai","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021031607395378300_bjs9302-bib-0041","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1755-1536-4-2","article-title":"The role of fibrocytes in fibrotic diseases of the lungs and heart","volume":"4","author":"Keeley","year":"2011","journal-title":"Fibrogenesis Tissue Repair"},{"key":"2021031607395378300_bjs9302-bib-0042","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jhep.2006.04.014","article-title":"Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis","volume":"45","author":"Kisseleva","year":"2006","journal-title":"J Hepatol"},{"key":"2021031607395378300_bjs9302-bib-0043","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbrc.2006.11.149","article-title":"Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease","volume":"353","author":"Mehrad","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"2021031607395378300_bjs9302-bib-0044","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1164\/rccm.200810-1534OC","article-title":"Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis","volume":"179","author":"Moeller","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2021031607395378300_bjs9302-bib-0045","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1164\/rccm.200710-1557OC","article-title":"Increased circulating fibrocytes in asthma with chronic airflow obstruction","volume":"178","author":"Wang","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"2021031607395378300_bjs9302-bib-0046","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.171.1.380","article-title":"Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma","volume":"171","author":"Schmidt","year":"2003","journal-title":"J Immunol"},{"key":"2021031607395378300_bjs9302-bib-0047","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00418-005-0072-2","article-title":"CD34 class III positive cells are present in atherosclerotic plaques of the rabbit model of atherosclerosis","volume":"124","author":"Zulli","year":"2005","journal-title":"Histochem Cell Biol"},{"key":"2021031607395378300_bjs9302-bib-0048","doi-asserted-by":"crossref","first-page":"18 284","DOI":"10.1073\/pnas.0608799103","article-title":"Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice","volume":"103","author":"Haudek","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021031607395378300_bjs9302-bib-0049","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1538-7836.2006.01924.x","article-title":"The role of the fibrocyte in intimal hyperplasia","volume":"4","author":"Varcoe","year":"2006","journal-title":"J Thromb Haemost"},{"key":"2021031607395378300_bjs9302-bib-0050","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1067-1927.2005.130407.x","article-title":"Identification of fibrocytes in postburn hypertrophic scar","volume":"13","author":"Yang","year":"2005","journal-title":"Wound Repair Regen"},{"key":"2021031607395378300_bjs9302-bib-0051","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1089\/jir.2007.0008","article-title":"Improvement in postburn hypertrophic scar after treatment with IFN-alpha2b is associated with decreased fibrocytes","volume":"27","author":"Wang","year":"2007","journal-title":"J Interferon Cytokine Res"},{"key":"2021031607395378300_bjs9302-bib-0052","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s004280100530","article-title":"CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions","volume":"440","author":"Barth","year":"2002","journal-title":"Virchows Arch"},{"key":"2021031607395378300_bjs9302-bib-0053","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.athoracsur.2011.04.065","article-title":"Circulating fibrocytes correlate with bronchiolitis obliterans syndrome development after lung transplantation: a novel clinical biomarker","volume":"92","author":"LaPar","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"2021031607395378300_bjs9302-bib-0054","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jaci.2008.10.048","article-title":"Fibrocyte localization to the airway smooth muscle is a feature of asthma","volume":"123","author":"Saunders","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"2021031607395378300_bjs9302-bib-0055","doi-asserted-by":"crossref","first-page":"c16","DOI":"10.1159\/000341374","article-title":"Circulating fibrocytes in ischemia\u2013reperfusion injury and chronic renal allograft fibrosis","volume":"121","author":"Kimura","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"2021031607395378300_bjs9302-bib-0056","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/HJH.0b013e3282f3e9e6","article-title":"The renin\u2013angiotensin system contributes to renal fibrosis through regulation of fibrocytes","volume":"26","author":"Sakai","year":"2008","journal-title":"J Hypertens"},{"key":"2021031607395378300_bjs9302-bib-0057","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1096\/fj.05-4295fje","article-title":"Characterization of human fibrocytes as circulating adipocyte progenitors and the formation of human adipose tissue in SCID mice","volume":"19","author":"Hong","year":"2005","journal-title":"FASEB J"},{"key":"2021031607395378300_bjs9302-bib-0058","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10620-009-0730-7","article-title":"Emergence of fibrocytes showing morphological changes in the inflamed colonic mucosa","volume":"55","author":"Uehara","year":"2010","journal-title":"Dig Dis Sci"},{"key":"2021031607395378300_bjs9302-bib-0059","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1524-475X.2006.00192.x","article-title":"Fibrocytes from burn patients regulate the activities of fibroblasts","volume":"15","author":"Wang","year":"2007","journal-title":"Wound Repair Regen"},{"key":"2021031607395378300_bjs9302-bib-0060","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1189\/jlb.1107782","article-title":"Pivotal advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation","volume":"83","author":"Shao","year":"2008","journal-title":"J Leukoc Biol"},{"key":"2021031607395378300_bjs9302-bib-0061","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.exphem.2005.10.008","article-title":"Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes","volume":"34","author":"Ebihara","year":"2006","journal-title":"Exp Hematol"},{"key":"2021031607395378300_bjs9302-bib-0062","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.biocel.2003.10.005","article-title":"Circulating fibrocytes: collagen-secreting cells of the peripheral blood","volume":"36","author":"Quan","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"2021031607395378300_bjs9302-bib-0063","doi-asserted-by":"crossref","first-page":"22 910","DOI":"10.1074\/jbc.M703597200","article-title":"Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma","volume":"282","author":"Hong","year":"2007","journal-title":"J Biol Chem"},{"key":"2021031607395378300_bjs9302-bib-0064","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03403533","article-title":"Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair","volume":"1","author":"Bucala","year":"1994","journal-title":"Mol Med"},{"key":"2021031607395378300_bjs9302-bib-0065","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yexcr.2004.11.011","article-title":"Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow","volume":"304","author":"Mori","year":"2005","journal-title":"Exp Cell Res"},{"key":"2021031607395378300_bjs9302-bib-0066","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/rcmb.2005-0239OC","article-title":"The role of CCL12 in the recruitment of fibrocytes and lung fibrosis","volume":"35","author":"Moore","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2021031607395378300_bjs9302-bib-0067","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00000372-200308000-00017","article-title":"Nephrogenic fibrosing dermopathy: suspect identified, motive unclear","volume":"25","author":"Cowper","year":"2003","journal-title":"Am J Dermatopathol"},{"key":"2021031607395378300_bjs9302-bib-0068","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1189\/jlb.0805456","article-title":"Aggregated IgG inhibits the differentiation of human fibrocytes","volume":"79","author":"Pilling","year":"2006","journal-title":"J Leukoc Biol"},{"key":"2021031607395378300_bjs9302-bib-0069","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"2021031607395378300_bjs9302-bib-0070","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.imbio.2006.05.025","article-title":"Migratory fate and differentiation of blood monocyte subsets","volume":"211","author":"Tacke","year":"2006","journal-title":"Immunobiology"},{"key":"2021031607395378300_bjs9302-bib-0071","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/labinvest.3700654","article-title":"The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses","volume":"87","author":"Bellini","year":"2007","journal-title":"Lab Invest"},{"key":"2021031607395378300_bjs9302-bib-0072","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1365-2559.2011.03911.x","article-title":"The connective tissue changes of Crohn's disease","volume":"60","author":"Shelley-Fraser","year":"2012","journal-title":"Histopathology"},{"key":"2021031607395378300_bjs9302-bib-0073","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.4049\/jimmunol.166.12.7556","article-title":"Peripheral blood fibrocytes: differentiation pathway and migration to wound sites","volume":"166","author":"Abe","year":"2001","journal-title":"J Immunol"},{"key":"2021031607395378300_bjs9302-bib-0074","doi-asserted-by":"crossref","first-page":"17 892","DOI":"10.1073\/pnas.0906070106","article-title":"CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes","volume":"106","author":"Niedermeier","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021031607395378300_bjs9302-bib-0075","first-page":"137","article-title":"Procollagen-III-peptide in the serum of patients with Crohn disease","volume":"27","author":"Loeschke","year":"1989","journal-title":"Z Gastroenterol"},{"key":"2021031607395378300_bjs9302-bib-0076","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-230X-4-29","article-title":"Elevated serum procollagen type III peptide in splanchnic and peripheral circulation of patients with inflammatory bowel disease submitted to surgery","volume":"4","author":"De Simone","year":"2004","journal-title":"BMC Gastroenterol"},{"key":"2021031607395378300_bjs9302-bib-0077","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/gut.37.6.805","article-title":"Seromarkers of collagen I and III metabolism in active Crohn's disease. Relation to disease activity and response to therapy","volume":"37","author":"Kjeldsen","year":"1995","journal-title":"Gut"},{"key":"2021031607395378300_bjs9302-bib-0078","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/jcp.56.11.817","article-title":"Serum laminin and collagen IV in inflammatory bowel disease","volume":"56","author":"Koutroubakis","year":"2003","journal-title":"J Clin Pathol"},{"key":"2021031607395378300_bjs9302-bib-0079","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/MOG.0b013e3282ff8b36","article-title":"Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science","volume":"24","author":"Rieder","year":"2008","journal-title":"Curr Opin Gastroenterol"},{"key":"2021031607395378300_bjs9302-bib-0080","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1007\/s00018-003-2328-0","article-title":"Fibrocytes: a unique cell population implicated in wound healing","volume":"60","author":"Metz","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"2021031607395378300_bjs9302-bib-0081","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/ibd.21106","article-title":"CXCL12 is a constitutive and inflammatory chemokine in the intestinal immune system","volume":"16","author":"Dotan","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"2021031607395378300_bjs9302-bib-0082","doi-asserted-by":"crossref","first-page":"e52332","DOI":"10.1371\/journal.pone.0052332","article-title":"IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?","volume":"7","author":"Bailey","year":"2012","journal-title":"PloS One"},{"key":"2021031607395378300_bjs9302-bib-0083","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1755-1536-3-23","article-title":"Toll-like receptor 2 agonists inhibit human fibrocyte differentiation","volume":"3","author":"Maharjan","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"2021031607395378300_bjs9302-bib-0084","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1053\/j.gastro.2007.02.056","article-title":"Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function","volume":"132","author":"Cario","year":"2007","journal-title":"Gastroenterology"},{"key":"2021031607395378300_bjs9302-bib-0085","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.biocel.2009.02.020","article-title":"Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis","volume":"41","author":"Mehrad","year":"2009","journal-title":"Int J Biochem Cell Biol"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.9302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/100\/12\/1549\/36612443\/bjs9302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/100\/12\/1549\/36612443\/bjs9302.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T10:10:13Z","timestamp":1621505413000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/100\/12\/1549-1556\/6138539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":85,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,10,9]]},"published-print":{"date-parts":[[2013,10,9]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.9302","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,11]]},"published":{"date-parts":[[2013,10,9]]}}}