{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:47:52Z","timestamp":1782604072363,"version":"3.54.5"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There are no randomized studies that compare outcomes after single-incision (SLC) and conventional multi-incision (MLC) laparoscopic cholecystectomy under an optimized perioperative analgesic regimen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This patient- and assessor-blinded randomized three-centre clinical trial compared SLC and MLC in women admitted electively with cholecystolithiasis. Outcomes were registered on the day of operation (day 0), on postoperative days 1, 2, 3 and 30, and 12 months after surgery. Blinding of the patients was maintained until day 3. The primary endpoint was pain on movement measured on a visual analogue scale, reported repeatedly by the patient until day 3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The intention-to-treat population comprised 59 patients in the SLC and 58 in the MLC group. There was no significant difference between the groups with regard to any of the pain-related outcomes, on-demand administration of opioids or general discomfort. Median duration of surgery was 32\u00b75 min longer in the SLC group (P &amp;lt; 0\u00b7001). SLC was associated with a reduced incidence of vomiting on day 0 (7 versus 22 per cent; P = 0\u00b7019). The incidences of wound-related problems were comparable. One patient in the SLC group experienced a biliary leak requiring endoscopic retrograde cholangiopancreatography. The rates of incisional hernia at 12-month follow-up were 2 per cent in both groups. Cosmetic rating was significantly improved after SLC at 1 and 12 months (P &amp;lt; 0\u00b7001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SLC did not significantly diminish early pain in a setting with optimized perioperative analgesic patient care. SLC may reduce postoperative vomiting. Registration number: NCT01268748 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9393","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T13:01:03Z","timestamp":1392642063000},"page":"347-355","source":"Crossref","is-referenced-by-count":55,"title":["Randomized clinical trial of single- <i>versus<\/i> multi-incision laparoscopic cholecystectomy"],"prefix":"10.1093","volume":"101","author":[{"given":"L N","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Surgery, Bispebjerg Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Al-Tayar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bispebjerg Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Assaadzadeh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Helgstrand","sequence":"additional","affiliation":[{"name":"Department of Surgery, K\u00f8ge Hospital, K\u00f8ge, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bisgaard","sequence":"additional","affiliation":[{"name":"Department of Surgery, K\u00f8ge Hospital, K\u00f8ge, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"issue":"4","key":"2021031209491180900_bjs9393-bib-0001","first-page":"CD006231","article-title":"Laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis","author":"Keus","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"2021031209491180900_bjs9393-bib-0002","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00464-001-9026-5","article-title":"Microlaparoscopic vs conventional laparoscopic cholecystectomy: a prospective randomized double-blind trial","volume":"16","author":"Bisgaard","year":"2002","journal-title":"Surg Endosc"},{"key":"2021031209491180900_bjs9393-bib-0003","first-page":"475","article-title":"Trans-umbilical cholecystectomy: a new laparoscopic cholecystectomy technique. 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