{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:31:52Z","timestamp":1787859112271,"version":"build-2784847793"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Transplanted organs carry the risk of inadvertent donor cancer transmission. Some cancers in organ donors have been classified as being associated with a high or unacceptable risk, but the evidence for such recommendations is scanty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The risk of cancer transmission from donors characterized as high or unacceptable risk was studied by analysing transplant and cancer registry data. Donors and recipients from England (1990\u20132008) were identified from the UK Transplant Registry. Cancer details were obtained from cancer registries and classified using guidelines from the Council of Europe and Organ Procurement and Transplantation Network\/United Network for Organ Sharing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 17 639 donors, 202 (1\u00b71 per cent) had a history of cancer, including 61 donors with cancers classed as having an unacceptable\/high risk of transmission. No cancer transmission was noted in 133 recipients of organs from these 61 donors. At 10 years after transplantation, the additional survival benefit gained by transplanting organs from donors with unacceptable\/high-risk cancer was 944 (95 per cent confidence interval (c.i.) 851 to 1037) life-years, with a mean survival of 7\u00b71 (95 per cent c.i. 6\u00b74 to 7\u00b78) years per recipient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Strict implementation of present guidelines is likely to result in overestimation of cancer transmission risk in some donors. Organs from some donors with cancers defined as unacceptable\/high risk can be used safely.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9460","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T07:06:52Z","timestamp":1398668812000},"page":"768-774","source":"Crossref","is-referenced-by-count":72,"title":["Estimated risk of cancer transmission from organ donor to graft recipient in a national transplantation registry"],"prefix":"10.1093","volume":"101","author":[{"given":"R","family":"Desai","sequence":"first","affiliation":[{"name":"NHS Blood and Transplant, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Collett","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J E","family":"Watson","sequence":"additional","affiliation":[{"name":"University Department of Surgery and Cambridge National Institute for Health Research Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Cancer Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Evans","sequence":"additional","affiliation":[{"name":"Public Health England, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Neuberger","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"2021031210195023500_bjs9460-bib-0001","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00007890-200208150-00011","article-title":"Transplant tumor registry: donor related malignancies","volume":"74","author":"Kauffman","year":"2002","journal-title":"Transplantation"},{"key":"2021031210195023500_bjs9460-bib-0002","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1097\/TP.0b013e318272df41","article-title":"Cancer transmission from organ donors \u2013 unavoidable but low risk","volume":"94","author":"Desai","year":"2012","journal-title":"Transplantation"},{"key":"2021031210195023500_bjs9460-bib-0003","author":"NHS Blood and Transplant","journal-title":"Transplant Activity in the UK: Archive Activity Reports 2001\u20132010"},{"key":"2021031210195023500_bjs9460-bib-0004","volume-title":"Inquiry Launched as Transplant Patients Contract Cancer","author":"BBC News"},{"key":"2021031210195023500_bjs9460-bib-0005","volume-title":"\u2018Cancer\u2019 Liver Transplant Killed Husband","author":"MailOnline"},{"key":"2021031210195023500_bjs9460-bib-0006","volume-title":"Soldier Dies after Receiving Smoker's Lungs in Transplant"},{"key":"2021031210195023500_bjs9460-bib-0007","volume-title":"Guide to the Safety and Quality Assurance for the Transplantation of Organs, Tissues and Cells","author":"Council of Europe, European Directorate for the Quality of Medicines and HealthCare","year":"2010","edition":"4th"},{"key":"2021031210195023500_bjs9460-bib-0008","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1600-6143.2011.03565.x","article-title":"Donor transmitted malignancies in organ transplantation: assessment of clinical risk","volume":"11","author":"Nalesnik","year":"2011","journal-title":"Am J Transplant"},{"key":"2021031210195023500_bjs9460-bib-0009","volume-title":"Potential Donor Audit: Summary Report for the 12 Month Period 01 April 2011\u00a0\u2013\u00a031 March 2012","author":"NHS Blood and Transplant"},{"key":"2021031210195023500_bjs9460-bib-0010","volume-title":"Organ Donation and Transplantation: Activity Report 2011\/12","author":"NHS Blood and Transplant"},{"key":"2021031210195023500_bjs9460-bib-0011","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/01.tp.0000267919.93425.fb","article-title":"Deceased donor with a past history of malignancy: an Organ Procurement and Transplantation Network\/United Network of Organ Sharing update","volume":"84","author":"Kauffman","year":"2007","journal-title":"Transplantation"},{"key":"2021031210195023500_bjs9460-bib-0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-6143.2010.03130.x","article-title":"How safe is it to transplant organs from deceased donors with primary intracranial malignancy? 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