{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:38Z","timestamp":1786977278711,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Classifications of intraductal papillary mucinous neoplasm (IPMN) remain ambiguous, especially for the mixed type. Factors predicting malignancy remain unclear. The aim of this study was to evaluate the usefulness of factors predicting malignancy in the new international consensus guidelines for resection of branch duct-type (BD)-IPMN and to compare them with those in the previous version.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospectively collected database of patients with biopsy-proven BD-IPMN was analysed to compare factors between the first and second consensus guidelines, particularly as predictors of malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 350 patients with BD-IPMN, sensitivity (0\u00b7724) and balanced accuracy (0\u00b7751) of the second guidelines were superior to those (0\u00b7639 and 0\u00b7730) in the first version at the expense of slightly reduced specificity (0\u00b7779 versus 0\u00b7822 for the first version) by random forest models. Multiple logistic regression analysis showed that main pancreatic duct dilatation greater than 5 mm (hazard ratio (HR) 4\u00b754, 95 per cent confidence interval 2\u00b745 to 8\u00b741; P &amp;lt; 0\u00b7001), mural nodules (HR 6\u00b727, 3\u00b727 to 12\u00b701; P &amp;lt; 0\u00b7001) and carbohydrate antigen 19\u20139 level above 37 units\/ml (HR 4\u00b703, 1\u00b783 to 8\u00b790; P = 0\u00b7001) were independent predictors of BD-IPMN malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The new consensus guidelines provide better sensitivity, performance of factors predicting malignancy, and balanced accuracy in the diagnosis of BD-IPMN malignancy. Size alone was limited in predicting malignancy. Variability in clinical significance of the individual factors associated with a risk of malignancy indicates the need for a tailored approach in the management of patients with BD-IPMN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.9491","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T12:39:29Z","timestamp":1395751169000},"page":"686-692","source":"Crossref","is-referenced-by-count":122,"title":["Validation of international consensus guidelines for the resection of branch duct-type intraductal papillary mucinous neoplasms"],"prefix":"10.1093","volume":"101","author":[{"given":"J-Y","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Statistics, Seoul National University College of Natural Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics, Seoul National University College of Natural Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Y","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Sejong University College of Natural Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K B","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y R","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-W","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"2021031618025452700_bjs9491-bib-0001","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-61024-0","volume-title":"World Health Organization International Histological Classification of Tumours: Histological Typing of Tumours of the Exocrine Pancreas (2nd edn)","author":"Kl\u00f6ppel","year":"1996"},{"key":"2021031618025452700_bjs9491-bib-0002","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000090023","article-title":"International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas","volume":"6","author":"Tanaka","year":"2006","journal-title":"Pancreatology"},{"key":"2021031618025452700_bjs9491-bib-0003","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pan.2012.04.004","article-title":"International Association of Pancreatology. 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