{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:08:15Z","timestamp":1790413695627,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":2485,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["08\/30\/02"],"award-info":[{"award-number":["08\/30\/02"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implementation of the National Health Service abdominal aortic aneurysm (AAA) screening programme (NAAASP) for men aged 65 years began in England in 2009. An important element of the evidence base supporting its introduction was the economic modelling of the long-term cost-effectiveness of screening, which was based mainly on 4-year follow-up data from the Multicentre Aneurysm Screening Study (MASS) randomized trial. Concern has been expressed about whether this conclusion of cost-effectiveness still holds, given the early performance parameters, particularly the lower prevalence of AAA observed in NAAASP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The existing published model was adjusted and updated to reflect the current best evidence. It was recalibrated to mirror the 10-year follow-up data from MASS; the main cost parameters were re-estimated to reflect current practice; and more robust estimates of AAA growth and rupture rates from recent meta-analyses were incorporated, as were key parameters as observed in NAAASP (attendance rates, AAA prevalence and size distributions).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The revised and updated model produced estimates of the long-term incremental cost-effectiveness of \u00a35758 (95 per cent confidence interval \u00a34285 to \u00a37410) per life-year gained, or \u00a37370 (\u00a35467 to \u00a39443) per quality-adjusted life-year (QALY) gained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the updated parameters, particularly the increased costs and lower AAA prevalence, have increased the cost per QALY, the latest modelling provides evidence that AAA screening as now being implemented in England is still highly cost-effective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.9528","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T10:31:33Z","timestamp":1401186693000},"page":"976-982","source":"Crossref","is-referenced-by-count":116,"title":["Cost-effectiveness of the National Health Service abdominal aortic aneurysm screening programme in England"],"prefix":"10.1093","volume":"101","author":[{"given":"M J","family":"Glover","sequence":"first","affiliation":[{"name":"Health Economics Research Group, Brunel University, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L G","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Sweeting","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Buxton","sequence":"additional","affiliation":[{"name":"Health Economics Research Group, Brunel University, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"2021031618033963500_bjs9528-bib-0001","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(02)11522-4","article-title":"The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial","volume":"360","author":"Ashton","year":"2002","journal-title":"Lancet"},{"key":"2021031618033963500_bjs9528-bib-0002","doi-asserted-by":"crossref","first-page":"699","DOI":"10.7326\/0003-4819-146-10-200705150-00003","article-title":"Multicentre Aneurysm Screening Study Group. 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