{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:10:46Z","timestamp":1777637446784,"version":"3.51.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The potential for surgical resection of primary hepatoblastoma tumours was assessed at diagnosis, and after two and four cycles of neoadjuvant chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Available radiographic images for patients with stage III and IV hepatoblastoma diagnosed between 1991 and 2008 were reviewed. The extent of disease was determined at diagnosis using the PRETEXT staging system, and after two and four cycles of therapy by POST-TEXT staging. Tumour resectability based on radiographic studies was assessed independently by two surgeons with expertise in hepatic surgery who were blinded to treatment and clinical outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Radiographic images from 20 patients with hepatoblastoma were reviewed. Six of 20 tumours were downstaged after two cycles, and three additional tumours were downstaged following four cycles. All PRETEXT stage III and IV tumours were determined to be surgically unresectable at diagnosis. The number of tumours considered unresectable decreased from 16 of 20 at diagnosis to seven of 20 after two cycles, and to four of 20 after four cycles. Five of the seven tumours that were unresectable after two cycles, and all four tumours that were unresectable after four cycles would have qualified for liver transplant based on radiographic studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The majority of stage III and IV hepatoblastomas achieved radiographic resectability after two cycles of chemotherapy. There may be an opportunity for earlier surgical intervention and potential for a reduction in chemotherapy in a considerable number of patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9681","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T11:23:48Z","timestamp":1414495428000},"page":"108-113","source":"Crossref","is-referenced-by-count":32,"title":["Effect of neoadjuvant chemotherapy on resectability of stage III and IV hepatoblastoma"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-106X","authenticated-orcid":false,"given":"R","family":"Venkatramani","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles , California,","place":["USA"]},{"name":"Department of Pediatrics, Keck School of Medicine, University of Southern California , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Stein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Children's Hospital Los Angeles , California,","place":["USA"]},{"name":"Department of Surgery, Keck School of Medicine, University of Southern California , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sapra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Keck School of Medicine, University of Southern California , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Genyk","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Keck School of Medicine, University of Southern California , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles , California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Malogolowkin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical College of Wisconsin , Milwaukee, Wisconsin,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles , California,","place":["USA"]},{"name":"Department of Pediatrics, Keck School of Medicine, University of Southern California , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2024092914162476300_bjs9681-bib-0001","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/cncr.10282","article-title":"Surgical view of the treatment of patients with hepatoblastoma: results from the first prospective trial of the International Society of Pediatric Oncology Liver Tumor Study Group","volume":"94","author":"Schnater","year":"2002","journal-title":"Cancer"},{"key":"2024092914162476300_bjs9681-bib-0002","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1200\/JCO.2000.18.14.2665","article-title":"Randomized comparison of cisplatin\/vincristine\/fluorouracil and cisplatin\/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group","volume":"18","author":"Ortega","year":"2000","journal-title":"J Clin Oncol"},{"key":"2024092914162476300_bjs9681-bib-0003","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF02306083","article-title":"Kinetics of primary tumor regression with chemotherapy: implications for the timing of surgery","volume":"3","author":"Medary","year":"1996","journal-title":"Ann Surg Oncol"},{"key":"2024092914162476300_bjs9681-bib-0004","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0959-8049(97)00095-6","article-title":"Efficiency and toxicity of ifosfamide, cisplatin and doxorubicin in the treatment of childhood hepatoblastoma. Study Committee of the Cooperative Paediatric Liver Tumour Study HB89 of the German Society for Paediatric Oncology and Haematology","volume":"33","author":"Von Schweinitz","year":"1997","journal-title":"Eur J Cancer"},{"key":"2024092914162476300_bjs9681-bib-0005","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1002\/cncr.26715","article-title":"Surgical management of children with locally advanced hepatoblastoma","volume":"118","author":"Meyers","year":"2012","journal-title":"Cancer"},{"key":"2024092914162476300_bjs9681-bib-0006","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00247-006-0361-5","article-title":"de Ville de Goyet J, Gauthier F et al. 2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group","volume":"37","author":"Roebuck","year":"2007","journal-title":"Pediatr Radiol"},{"key":"2024092914162476300_bjs9681-bib-0007","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jpedsurg.2009.10.023","article-title":"Defining hepatoblastoma responsiveness to induction therapy as measured by tumor volume and serum alpha-fetoprotein kinetics","volume":"45","author":"Lovvorn","year":"2010","journal-title":"J Pediatr Surg"},{"key":"2024092914162476300_bjs9681-bib-0008","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jpedsurg.2004.01.035","article-title":"Association between surgical margins and long-term outcome in advanced hepatoblastoma","volume":"39","author":"Dicken","year":"2004","journal-title":"J Pediatr Surg"},{"key":"2024092914162476300_bjs9681-bib-0009","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1002\/cncr.25722","article-title":"Successful nontransplant resection of POST-TEXT III and IV hepatoblastoma","volume":"117","author":"Lautz","year":"2011","journal-title":"Cancer"},{"key":"2024092914162476300_bjs9681-bib-0010","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jpedsurg.2013.03.019","article-title":"Imaging analysis of hepatoblastoma resectability across neoadjuvant chemotherapy","volume":"48","author":"Murphy","year":"2013","journal-title":"J Pediatr Surg"},{"key":"2024092914162476300_bjs9681-bib-0011","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejca.2003.06.003","article-title":"Risk-adapted treatment for childhood hepatoblastoma: final report of the second study of the International Society of Paediatric Oncology \u2013 SIOPEL 2","volume":"40","author":"Perilongo","year":"2004","journal-title":"Eur J Cancer"},{"key":"2024092914162476300_bjs9681-bib-0012","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/pbc.24038","article-title":"Tumor necrosis predicts survival following neo-adjuvant chemotherapy for hepatoblastoma","volume":"59","author":"Venkatramani","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"2024092914162476300_bjs9681-bib-0013","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1200\/JCO.2009.22.4857","article-title":"Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study","volume":"28","author":"Zs\u00edros","year":"2010","journal-title":"J Clin Oncol"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.9681","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/102\/1\/108\/59433105\/bjs9681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/102\/1\/108\/59433105\/bjs9681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T14:16:58Z","timestamp":1727619418000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/102\/1\/108\/6136648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.9681","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,1]]},"published":{"date-parts":[[2015,1,1]]}}}