{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:20:54Z","timestamp":1788520854487,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["PB-PG-0909-20150"],"award-info":[{"award-number":["PB-PG-0909-20150"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sacral nerve stimulation (SNS) is a well established therapy for faecal incontinence (FI). Percutaneous tibial nerve stimulation (PTNS) is a newer, less invasive, treatment. The effectiveness and acceptability of these treatments have not been compared systematically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An investigator-blinded randomized pilot trial of PTNSversus SNS with a parallel qualitative study was performed. Quantitative clinical outcomes and qualitative data from patient interviews were collected for both interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty patients (39 women; mean age 59 years) met the eligibility criteria; 23 were randomized to receive SNS and 17 to PTNS. Fifteen patients progressed to permanent SNS implantation and 16 received a full course of PTNS. Within-group effect sizes were marginally greater for SNS than for PTNS on available-case analysis. Mean(s.d.) FI episodes per week at baseline, and 3 and 6 months of follow-up were: 11\u00b74(12\u00b70), 4\u00b70(4\u00b70) and 4\u00b79(6\u00b79) respectively for SNS compared with 10\u00b76(11\u00b72), 5\u00b78(6\u00b79) and 6\u00b73(6\u00b79) for PTNS. Mean(s.d.) Cleveland Clinic Incontinence Score values at baseline, and 3 and 6 months were: 16\u00b72(3\u00b70), 11\u00b71(5\u00b72) and 10\u00b74(5\u00b76) for SNSversus 15\u00b71(2\u00b77), 11\u00b77(4\u00b74) and 12\u00b71(5\u00b72) for PTNS. Improvement of at least 50 per cent in FI episodes per week at 6 months was seen in 11 of 18 patients in the SNS group compared with seven of 15 in the PTNS group. Effect estimates for SNS with chronic implanted stimulation were larger (10 of 15 patients at 6 months). Disease-specific and generic quality-of-life improvements complemented clinical outcome data. Qualitative analysis of interview data suggested that both treatments had high acceptability amongst patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the short term, both SNS and PTNS provide some clinical benefit to patients with FI. Registration numbers: 2010-018728-15 and 10479 (http:\/\/public.ukcrn.org.uk\/search\/StudyDetail.aspx?StudyID=10479).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.9695","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T06:20:44Z","timestamp":1422426044000},"page":"349-358","source":"Crossref","is-referenced-by-count":80,"title":["Randomized clinical trial of sacral\n                    <i>versus<\/i>\n                    percutaneous tibial nerve stimulation in patients with faecal incontinence"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-3797","authenticated-orcid":false,"given":"N N","family":"Thin","sequence":"first","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation, Centre for Digestive Diseases, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J 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Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N S","family":"Williams","sequence":"additional","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation, Centre for Digestive Diseases, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Knowles","sequence":"additional","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation, Centre for Digestive Diseases, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Alam","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Unit, University College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bannister","sequence":"additional","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation, Centre for Primary Care and Public Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Scott","sequence":"additional","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation, Centre for Primary Care and Public Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Allison","sequence":"additional","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation, Centre for Primary Care and Public Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Vaizey","sequence":"additional","affiliation":[{"name":"The Sir Alan Parks Department of Physiology, St Mark's Hospital and Academic Institute, Harrow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Thomas","sequence":"additional","affiliation":[{"name":"The Sir Alan Parks Department of Physiology, St Mark's Hospital and Academic Institute, Harrow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"2021021717275869000_bjs9695-bib-0001","volume-title":"Faecal Incontinence: The Management of Faecal Incontinence in Adults","author":"National Institute for Health and Care Excellence"},{"key":"2021021717275869000_bjs9695-bib-0002","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1111\/j.1463-1318.2011.02650.x","article-title":"Sacral nerve stimulation for faecal incontinence: patient selection, service provision and operative 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