{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:54:21Z","timestamp":1762761261990},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Real-time tissue elastography is an innovative tool that informs the surgeon about tissue elasticity by applying the principle of ultrasonography. The aim of this study was to investigate the accuracy of intraoperative real-time tissue elastography (IORTE) for the detection and characterization of liver tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between October 2010 and November 2011, IORTE was performed for liver lesions after the completion of routine B-mode intraoperative ultrasonography (IOUS). The elasticity images of all tumours, except those of cysts, were classified into six categories according to modified criteria (types 1\u20136), according to the degree of strain contrast with the surrounding liver. The concordance of IORTE with pathological examination of the tumour, B-mode IOUS and clinical diagnosis after follow-up was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Images were obtained from 92 hepatocellular carcinomas (HCCs), 92 adenocarcinomas, 19 other malignant tumours and 18 benign tumours in 158 patients. Using a minilinear probe, 73 of 88 HCCs were classified as having a \u2018HCC pattern\u2019 (type 3, 4 or 5), resulting in a sensitivity of 83\u00b70 per cent, a specificity of 67\u00b72 per cent and an accuracy of 73\u00b77 per cent. Some 66 of 90 adenocarcinomas were classified as \u2018adenocarcinoma pattern\u2019 (type 6), resulting in a sensitivity of 73\u00b73 per cent, specificity of 95\u00b71 per cent and accuracy of 85\u00b79 per cent. IORTE detected seven new lesions (8 per cent).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>IORTE is useful for the detection and characterization of liver tumours.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9728","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T16:09:35Z","timestamp":1419350975000},"page":"246-253","source":"Crossref","is-referenced-by-count":14,"title":["Differential diagnosis of liver tumours using intraoperative real-time tissue elastography"],"prefix":"10.1093","volume":"102","author":[{"given":"K","family":"Omichi","sequence":"first","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Inoue","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Okinaga","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Aoki","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Kurahashi","sequence":"additional","affiliation":[{"name":"iAnalysis LLC , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Kokudo","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,2,1]]},"reference":[{"key":"2024092914151943500_bjs9728-bib-0001","first-page":"493","article-title":"Intraoperative ultrasonic examination for hepatectomy","author":"Makuuchi","year":"1983","journal-title":"Ultrasound Med Biol"},{"key":"2024092914151943500_bjs9728-bib-0002","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1007\/s00464-006-9192-6","article-title":"Intraoperative ultrasonography during planned liver resections: why are we still performing it?","volume":"21","author":"Ellsmere","year":"2007","journal-title":"Surg Endosc"},{"key":"2024092914151943500_bjs9728-bib-0003","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/archsurg.142.12.1170","article-title":"Detection of new tumors by intraoperative ultrasonography during repeated hepatic resections for hepatocellular carcinoma","volume":"142","author":"Zhang","year":"2007","journal-title":"Arch Surg"},{"key":"2024092914151943500_bjs9728-bib-0004","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1478-3231.2007.01583.x","article-title":"Intra-operative ultrasound for detection of liver metastases from colorectal cancer","volume":"28","author":"Mazzoni","year":"2008","journal-title":"Liver Int"},{"key":"2024092914151943500_bjs9728-bib-0005","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s11605-011-1810-5","article-title":"Intraoperative detection of disappearing colorectal liver metastases as a predictor of residual disease","volume":"16","author":"Ferrero","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"2024092914151943500_bjs9728-bib-0006","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1477-2574.2011.00349.x","article-title":"Is intra-operative ultrasound still useful for the detection of a hepatic tumour in the era of modern pre-operative imaging?","volume":"13","author":"D'Hondt","year":"2011","journal-title":"HPB (Oxford)"},{"key":"2024092914151943500_bjs9728-bib-0007","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF01655837","article-title":"The use of operative ultrasound as an aid to liver resection in patients with hepatocellular carcinoma","volume":"11","author":"Makuuchi","year":"1987","journal-title":"World J Surg"},{"key":"2024092914151943500_bjs9728-bib-0008","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1002\/lt.20050","article-title":"Contrast-enhanced intraoperative ultrasonography in surgery for hepatocellular carcinoma in cirrhosis","volume":"10","author":"Torzilli","year":"2004","journal-title":"Liver Transpl"},{"key":"2024092914151943500_bjs9728-bib-0009","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1097\/SLA.0b013e31822518be","article-title":"Usefulness of contrast-enhanced intraoperative ultrasound using Sonazoid in patients with hepatocellular carcinoma","volume":"254","author":"Arita","year":"2011","journal-title":"Ann Surg"},{"key":"2024092914151943500_bjs9728-bib-0010","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/01.sla.0000197708.77063.07","article-title":"Potential value of contrast-enhanced intraoperative ultrasonography during partial hepatectomy for metastases: an essential investigation before resection?","volume":"243","author":"Leen","year":"2006","journal-title":"Ann Surg"},{"key":"2024092914151943500_bjs9728-bib-0011","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/bjs.8844","article-title":"Contrast-enhanced intraoperative ultrasonography using perfluorobutane microbubbles for the enumeration of colorectal liver metastases","volume":"99","author":"Takahashi","year":"2012","journal-title":"Br J Surg"},{"key":"2024092914151943500_bjs9728-bib-0012","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/016173469101300201","article-title":"Elastography: a quantitative method for imaging the elasticity of biological tissues","volume":"13","author":"Ophir","year":"1991","journal-title":"Ultrason Imaging"},{"key":"2024092914151943500_bjs9728-bib-0013","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02481234","article-title":"Real time tissue elasticity imaging using the combined autocorrelation method","volume":"29","author":"Shiina","year":"2002","journal-title":"J Med Ultrason"},{"key":"2024092914151943500_bjs9728-bib-0014","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1088\/0031-9155\/45\/6\/302","article-title":"New real-time strain imaging concepts using diagnostic ultrasound","volume":"45","author":"Pesavento","year":"2000","journal-title":"Phys Med Biol"},{"key":"2024092914151943500_bjs9728-bib-0015","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1148\/radiol.2391041676","article-title":"Breast disease: clinical application of US elastography for diagnosis","volume":"239","author":"Itoh","year":"2006","journal-title":"Radiology"},{"key":"2024092914151943500_bjs9728-bib-0016","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1148\/radiol.2363041248","article-title":"Thyroid gland tumor diagnosis at US elastography","volume":"237","author":"Lyshchik","year":"2005","journal-title":"Radiology"},{"key":"2024092914151943500_bjs9728-bib-0017","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s10147-007-0669-7","article-title":"The impact of real-time tissue elasticity imaging (elastography) on the detection of prostate cancer: clinicopathological analysis","volume":"12","author":"Tsutsumi","year":"2007","journal-title":"Int J Clin Oncol"},{"key":"2024092914151943500_bjs9728-bib-0018","doi-asserted-by":"crossref","first-page":"758","DOI":"10.2214\/AJR.06.0322","article-title":"Real-time elastography for noninvasive assessment of liver fibrosis in chronic viral hepatitis","volume":"188","author":"Friedrich-Rust","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"2024092914151943500_bjs9728-bib-0019","first-page":"439","article-title":"Real time elastography \u2013 a non-invasive diagnostic method of small hepatocellular carcinoma in cirrhosis","volume":"18","author":"Gheorghe","year":"2009","journal-title":"J Gastrointest Liver Dis"},{"key":"2024092914151943500_bjs9728-bib-0020","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00534-009-0075-9","article-title":"Real time elastography for noninvasive diagnosis of liver fibrosis","volume":"16","author":"Kanamoto","year":"2009","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"2024092914151943500_bjs9728-bib-0021","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1148\/radiol.10100319","article-title":"Liver fibrosis in patients with chronic hepatitis C: noninvasive diagnosis by means of real-time tissue elastography \u2013 establishment of the method for measurement","volume":"258","author":"Koizumi","year":"2011","journal-title":"Radiology"},{"key":"2024092914151943500_bjs9728-bib-0022","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00535-010-0301-x","article-title":"Real-time tissue elastography as a tool for the noninvasive assessment of liver stiffness in patients with chronic hepatitis C","volume":"46","author":"Morikawa","year":"2011","journal-title":"J Gastroenterol"},{"key":"2024092914151943500_bjs9728-bib-0023","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.surg.2010.02.009","article-title":"Intra-operative freehand real-time elastography for small focal liver lesions","volume":"148","author":"Inoue","year":"2010","journal-title":"Surgery"},{"key":"2024092914151943500_bjs9728-bib-0024","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/j.1478-3231.2008.01701.x","article-title":"Intra-operative application of real-time tissue elastography for the diagnosis of liver tumours","volume":"28","author":"Kato","year":"2008","journal-title":"Liver Int"},{"key":"2024092914151943500_bjs9728-bib-0025","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s00268-011-1264-7","article-title":"Value of visual inspection, bimanual palpation, and intraoperative ultrasonography during hepatic resection for liver metastases of colorectal carcinoma","volume":"35","author":"Hata","year":"2011","journal-title":"World J Surg"},{"key":"2024092914151943500_bjs9728-bib-0026","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1148\/radiol.2523081928","article-title":"Liver fibrosis in viral hepatitis: noninvasive assessment with acoustic radiation force impulse imaging versus transient elastography","volume":"252","author":"Friedrich-Rust","year":"2009","journal-title":"Radiology"},{"key":"2024092914151943500_bjs9728-bib-0027","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ultrasmedbio.2003.07.001","article-title":"Transient elastography: a new noninvasive method for assessment of hepatic fibrosis","volume":"29","author":"Sandrin","year":"2003","journal-title":"Ultrasound Med Biol"},{"key":"2024092914151943500_bjs9728-bib-0028","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.acra.2011.01.026","article-title":"Usefulness of acoustic radiation force impulse imaging in the differential diagnosis of benign and malignant liver lesions","volume":"18","author":"Shuang-Ming","year":"2011","journal-title":"Acad Radiol"},{"key":"2024092914151943500_bjs9728-bib-0029","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1259\/bjr\/97637841","article-title":"Acoustic radiation force impulse elastography in distinguishing hepatic haemangiomata from metastases: preliminary observations","volume":"84","author":"Davies","year":"2011","journal-title":"Br J Radiol"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.9728","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/102\/3\/246\/59433008\/bjs9728.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/102\/3\/246\/59433008\/bjs9728.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T14:15:28Z","timestamp":1727619328000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/102\/3\/246\/6136471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,27]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,1,27]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.9728","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[2015,2]]},"published":{"date-parts":[[2015,1,27]]}}}