{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:57:19Z","timestamp":1793447839475,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this analysis was to assess the predictive value of C-reactive protein (CRP) for the early detection of postoperative infectious complications after a variety of abdominal operations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A meta-analysis of seven cohort studies from a single institution was performed. Laparoscopic gastric bypass and colectomies, as well as open resections of cancer of the colon, rectum, pancreas, stomach and oesophagus, were included. The predictive value of CRP was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 1986 patients, 577 (29\u00b71 (95 per cent c.i. 27\u00b71 to 31\u00b73) per cent) had at least one postoperative infectious complication. Patients undergoing laparoscopic gastric bypass (383 patients) or colectomy (285), and those having open gastric (97) or colorectal (934) resections were combined in a meta-analysis. Patients who had resection for cancer of the oesophagus (41) or pancreas (246) were analysed separately owing to heterogeneity. CRP levels 4 days after surgery had the highest diagnostic accuracy (AUC 0\u00b776, 95 per cent c.i. 0\u00b773 to 0\u00b778). Sensitivity and specificity were 68\u00b75 (60\u00b76 to 75\u00b75) and 71\u00b76 (66\u00b76 to 76\u00b70) per cent respectively. Positive and negative predictive values were 50\u00b74 (46\u00b70 to 54\u00b78) and 84\u00b73 (80\u00b78 to 87\u00b73) per cent. The threshold CRP varied according to the procedure performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The negative predictive value of serum CRP concentration on day 4 after surgery facilitates reliable exclusion of postoperative infectious complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9756","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T13:36:32Z","timestamp":1426512992000},"page":"590-598","source":"Crossref","is-referenced-by-count":127,"title":["Meta-analysis of the predictive value of C-reactive protein for infectious complications in abdominal surgery"],"prefix":"10.1093","volume":"102","author":[{"given":"M","family":"Adamina","sequence":"first","affiliation":[{"name":"Departments of Surgery, Kantonsspital Winterthur, Winterthur, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Steffen","sequence":"additional","affiliation":[{"name":"Kantonsspital St Gallen, St Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Kantonsspital St Gallen, St Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Beutner","sequence":"additional","affiliation":[{"name":"Kantonsspital St Gallen, St Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B M","family":"Schmied","sequence":"additional","affiliation":[{"name":"Kantonsspital St Gallen, St Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Warschkow","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Kantonsspital Winterthur, Winterthur, Switzerland"},{"name":"Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"2021021717483392900_bjs9756-bib-0001","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"2021021717483392900_bjs9756-bib-0002","doi-asserted-by":"crossref","first-page":"R167","DOI":"10.1186\/cc8138","article-title":"One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study","volume":"13","author":"Puskarich","year":"2009","journal-title":"Crit Care"},{"key":"2021021717483392900_bjs9756-bib-0003","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1378\/chest.10-1405","article-title":"Point: adherence to early goal-directed therapy: does it really matter? 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