{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:47:09Z","timestamp":1784605629445,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although anorectal transplantation is a challenging procedure, it is a promising option for patients who have completely lost anorectal function or in whom it failed to develop, as in congenital malformations. The paucity of animal models with which to test functional outcomes was addressed in this study of anorectal manometry in rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Wistar rats were assigned randomly to four groups: orthotopic anorectal transplantation, heterotopic transplantation, sham operation, or normal control. Bodyweight and anal pressure were measured immediately before and after operation, and on postoperative days 7 and 14. ANOVA and Tukey's test were used to compare results for bodyweight, anal manometry and length of procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Immediately after the procedure, mean(s.d.) anal pressure in the orthotopic group (n = 13) dropped from 31\u00b74(13\u00b71) to 1\u00b76(13\u00b71) cmH2O (P &amp;lt; 0\u00b7001 versus both sham operation (n = 13) and normal control (n = 15)), with partial recovery on postoperative day 7 (14\u00b79(13\u00b79) cmH2O) (P = 0\u00b7009 versus normal control) and complete recovery on day 14 (23\u00b77(12\u00b72) cmH2O). Heterotopic rats (n = 14) demonstrated partial functional recovery: mean(s.d.) anal pressure was 26\u00b79(10\u00b79) cmH2O before operation and 8\u00b76(6\u00b78) cmH2O on postoperative day 14 (P &amp;lt; 0\u00b7001 versus both sham and normal control).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Orthotopic anorectal transplantation may result in better functional outcomes than heterotopic procedures.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9762","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T11:22:48Z","timestamp":1424258568000},"page":"558-562","source":"Crossref","is-referenced-by-count":7,"title":["Functional outcome of autologous anorectal transplantation in an experimental model"],"prefix":"10.1093","volume":"102","author":[{"given":"V E","family":"Seid","sequence":"first","affiliation":[{"name":"Laboratory of Liver Transplantation and Experimental Surgery (LIM-37), Division of Liver Transplantation, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Division of Colorectal Surgery, Department of Gastroenterology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F H F","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Liver Transplantation and Experimental Surgery (LIM-37), Division of Liver Transplantation, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery, Oxford University Hospitals and University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Waisberg","sequence":"additional","affiliation":[{"name":"Laboratory of Liver Transplantation and Experimental Surgery (LIM-37), Division of Liver Transplantation, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"R J","family":"Cruz","sequence":"additional","affiliation":[{"name":"Intestinal Rehabilitation and Transplant Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Chaib","sequence":"additional","affiliation":[{"name":"Laboratory of Liver Transplantation and Experimental Surgery (LIM-37), Division of Liver Transplantation, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S C","family":"Nahas","sequence":"additional","affiliation":[{"name":"Division of 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