{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:22:11Z","timestamp":1784550131674,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The optimal technique for curative resection of colonic cancer includes high ligation of the mesenteric vessels, wide excision of the colonic mesentery and prevention of tumour cell spillage. This article reports results from the authors' institution for patients in whom complete mesocolic excision was performed long before the term was coined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients operated on for cure for primary adenocarcinoma of the colon between January 1994 and December 2004 were identified from a prospectively maintained, institutional review board-approved, colorectal cancer registry. Medical records and operation notes were reviewed. The primary outcomes were recurrence (local and distal) and age-adjusted 5-year survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 1013 patients (560 men and 453 women) were identified, with a median age of 69 (range 21\u201396) years. The most common location of the cancer was the sigmoid colon (32\u00b79 per cent), followed by the caecum (26\u00b77 per cent) and ascending colon (17\u00b70 per cent). Operations were performed laparoscopically in 134 patients (13\u00b72 per cent). Median duration of hospital stay was 7 (range 1\u201364, mean 8\u00b72) days. Overall morbidity and mortality rates were 13\u00b75 and 2\u00b72 per cent respectively; there were 20 anastomotic leaks (2\u00b70 per cent). Some 282 patients (27\u00b78 per cent) had stage I, 386 (38\u00b71 per cent) stage II and 345 (34\u00b71 per cent) stage III disease. Median lymph node yield was 28\u00b73 (range 0\u2013241, mean 28\u00b73), and 12 or more nodes were examined in 88\u00b71 per cent of patients. Adjuvant chemotherapy was administered to 277 patients (80\u00b73 per cent) with stage III disease. Overall local and distant recurrence rates at 5 years were 5\u00b71 and 17\u00b71 per cent respectively. The 5-year local recurrence rate was 2\u00b72, 5\u00b73 and 7\u00b77 per cent for American Joint Committee on Cancer stages I, II and III respectively. Corresponding distant recurrence rates were 4\u00b70, 14\u00b77 and 30\u00b75 per cent. The 5-year overall cancer-free age-standardized survival rate was 85\u00b73 per cent. Five-year age standardized survival rates for patients with disease stages I, II and III were 97\u00b77, 90\u00b78 and 69\u00b78 per cent respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These data define modern results of surgery for colonic cancer with conservative use of chemotherapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9805","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T22:15:41Z","timestamp":1428012941000},"page":"847-852","source":"Crossref","is-referenced-by-count":38,"title":["Primacy of surgery for colorectal cancer"],"prefix":"10.1093","volume":"102","author":[{"given":"J","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Remzi","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hull","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"2021022218335254400_bjs9805-bib-0001","first-page":"722","article-title":"Physiologic resection of the right colon","volume":"94","author":"Barnes","year":"1952","journal-title":"Surg Gynecol Obstet"},{"key":"2021022218335254400_bjs9805-bib-0002","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/jama.1975.03240230053026","article-title":"Current concepts in cancer. 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