{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:57:06Z","timestamp":1780595826117,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>More than 60 per cent of patients treated surgically for primary retroperitoneal sarcoma survive for at least 5 years. Extended surgical resection has been proposed for primary disease, but long-term morbidity data are lacking. A cross-sectional study was conducted to assess the long-term morbidity of patients undergoing surgery for retroperitoneal sarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients operated on between January 2002 and December 2011 were eligible for the study. Long-term morbidity was evaluated based on a semistructured clinical interview. Lower limb function was assessed by means of the Lower Extremity Functional Scale (LEFS), a self-report questionnaire with a total score ranging from 0 (low functioning) to 80 (high functioning). Pain was investigated by means of the Brief Pain Inventory \u2013 Short Form, with pain intensity scores reported on a scale from 0 (no pain) to 10 (worst pain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Some 243 patients underwent surgery, and 101 of 160 patients who were alive at the time of the investigation responded to the study invitation letter. Finally, 95 patients were enrolled in the study. Sensory impairment of the limbs was reported in 72 patients (76 per cent). The median LEFS score was 60 (i.q.r. 43\u201373). Mean scores for the pain intensity items varied from 1\u00b723 to 2\u00b768. In multivariable analysis, there was no difference in median levels of creatinine at survey between patients who did or did not undergo nephrectomy (difference between median values 13 (95 per cent c.i. \u22124 to 30) \u00b5mol\/l; P = 0\u00b7170).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe chronic pain and lower limb motor impairment after multivisceral resection for retroperitoneal sarcomas are rare. Long-term renal function is not significantly impaired when nephrectomy is performed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.9829","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T03:01:19Z","timestamp":1433386879000},"page":"1079-1087","source":"Crossref","is-referenced-by-count":50,"title":["Long-term morbidity after multivisceral resection for retroperitoneal sarcoma"],"prefix":"10.1093","volume":"102","author":[{"given":"D","family":"Callegaro","sequence":"first","affiliation":[{"name":"Department of Surgery, Pain Therapy and Rehabilitation Unit, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Miceli","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Pain Therapy and Rehabilitation Unit, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Palliative Care, Pain Therapy and Rehabilitation Unit, Milan, Italy"},{"name":"European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pain Therapy and Rehabilitation Unit, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Radaelli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pain Therapy and Rehabilitation Unit, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P G","family":"Casali","sequence":"additional","affiliation":[{"name":"Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Caraceni","sequence":"additional","affiliation":[{"name":"Palliative Care, Pain Therapy and Rehabilitation Unit, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gronchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pain Therapy and Rehabilitation Unit, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-424X","authenticated-orcid":false,"given":"M","family":"Fiore","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pain Therapy and Rehabilitation Unit, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"2021022218481505800_bjs9829-bib-0001","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1245\/s10434-011-1746-8","article-title":"Surgery in retroperitoneal soft tissue sarcoma: a call for a consensus between Europe and North America","volume":"18","author":"Gronchi","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0002","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/jso.23463","article-title":"Management of recurrent retroperitoneal sarcoma","volume":"109","author":"Gyorki","year":"2014","journal-title":"J Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0003","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1245\/s10434-011-1742-z","article-title":"Retroperitoneal sarcoma: is it time to change the surgical policy?","volume":"18","author":"Mussi","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0004","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1245\/s10434-014-3965-2","article-title":"Management of primary retroperitoneal sarcoma (RPS) in the adult: a consensus approach from the Trans-Atlantic RPS Working Group","volume":"22","author":"Trans-Atlantic RPS Working Group","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00000658-199809000-00008","article-title":"Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution","volume":"228","author":"Lewis","year":"1998","journal-title":"Ann Surg"},{"key":"2021022218481505800_bjs9829-bib-0006","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1200\/JCO.1997.15.8.2832","article-title":"Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management","volume":"15","author":"Heslin","year":"1997","journal-title":"J Clin Oncol"},{"key":"2021022218481505800_bjs9829-bib-0007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1200\/JCO.2008.18.0802","article-title":"Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control","volume":"27","author":"Bonvalot","year":"2009","journal-title":"J Clin Oncol"},{"key":"2021022218481505800_bjs9829-bib-0008","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jamcollsurg.2013.10.009","article-title":"Predictors of outcomes in patients with primary retroperitoneal dedifferentiated liposarcoma undergoing surgery","volume":"218","author":"Keung","year":"2014","journal-title":"J Am Coll Surg"},{"key":"2021022218481505800_bjs9829-bib-0009","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1002\/cncr.25057","article-title":"Histology-specific nomogram for primary retroperitoneal soft tissue sarcoma","volume":"116","author":"Ardoino","year":"2010","journal-title":"Cancer"},{"key":"2021022218481505800_bjs9829-bib-0010","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.sla.0000086542.11899.38","article-title":"Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma","volume":"238","author":"Singer","year":"2003","journal-title":"Ann Surg"},{"key":"2021022218481505800_bjs9829-bib-0011","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1245\/ASO.2004.09.005","article-title":"Evaluation of a clinically applicable post-surgical classification system for primary retroperitoneal soft-tissue sarcoma","volume":"11","author":"van Dalen","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0012","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1245\/s10434-013-2971-0","article-title":"Quality of local treatment or biology of the tumor: which are the trump cards for loco-regional control of retroperitoneal sarcoma?","volume":"20","author":"Gronchi","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0013","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/SLA.0b013e3181b25183","article-title":"Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging system","volume":"250","author":"Nathan","year":"2009","journal-title":"Ann Surg"},{"key":"2021022218481505800_bjs9829-bib-0014","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1200\/JCO.2012.44.3747","article-title":"Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets","volume":"31","author":"Gronchi","year":"2013","journal-title":"J Clin Oncol"},{"key":"2021022218481505800_bjs9829-bib-0015","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1245\/s10434-012-2342-2","article-title":"Technical considerations in surgery for retroperitoneal sarcomas: position paper from E-Surge, a master class in sarcoma surgery, and EORTC-STBSG","volume":"19","author":"Bonvalot","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0016","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1200\/JCO.2008.17.8871","article-title":"Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients","volume":"27","author":"Gronchi","year":"2009","journal-title":"J Clin Oncol"},{"key":"2021022218481505800_bjs9829-bib-0017","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/annonc\/mdr323","article-title":"Frontline extended surgery is associated with improved survival in retroperitoneal low- to intermediate-grade soft tissue sarcomas","volume":"23","author":"Gronchi","year":"2012","journal-title":"Ann Oncol"},{"key":"2021022218481505800_bjs9829-bib-0018","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1245\/s10434-010-1057-5","article-title":"Aggressive surgery in retroperitoneal soft tissue sarcoma carried out at high-volume centers is safe and is associated with improved local control","volume":"17","author":"Bonvalot","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0019","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"2021022218481505800_bjs9829-bib-0020","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"2021022218481505800_bjs9829-bib-0021","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(95)00156-5","article-title":"A validation study of an Italian version of the Brief Pain Inventory (Breve Questionario per la Valutazione del Dolore)","volume":"65","author":"Caraceni","year":"1996","journal-title":"Pain"},{"key":"2021022218481505800_bjs9829-bib-0022","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jclinepi.2009.08.001","article-title":"The Italian version of the lower extremity functional scale was reliable, valid, and responsive","volume":"63","author":"Cacchio","year":"2010","journal-title":"J Clin Epidemiol"},{"key":"2021022218481505800_bjs9829-bib-0023","volume-title":"Analysing Survival Data for Clinical Trials and Observational Studies","author":"Marubini","year":"1995"},{"key":"2021022218481505800_bjs9829-bib-0024","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"2021022218481505800_bjs9829-bib-0025","author":"The R Foundation","year":"2015","journal-title":"The R Project for Statistical Computing"},{"key":"2021022218481505800_bjs9829-bib-0026","article-title":"Personalizing the approach to retroperitoneal soft tissue sarcoma: histology-specific patterns of failure and postrelapse outcome after primary extended resection","author":"Gronchi","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"2021022218481505800_bjs9829-bib-0027","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1200\/JCO.2008.18.7138","article-title":"Resection of some \u2013 but not all \u2013 clinically uninvolved adjacent viscera as part of surgery for retroperitoneal soft tissue sarcomas","volume":"27","author":"Pisters","year":"2009","journal-title":"J Clin Oncol"},{"key":"2021022218481505800_bjs9829-bib-0028","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1245\/s10434-010-1061-9","article-title":"Are radical compartmental resections for retroperitoneal sarcomas justified?","volume":"17","author":"Raut","year":"2010","journal-title":"Ann Surg Oncol"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.9829","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/102\/9\/1079\/36336927\/bjs9829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/102\/9\/1079\/36336927\/bjs9829.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T10:05:35Z","timestamp":1717927535000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/102\/9\/1079-1087\/6136570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,3]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,6,3]]},"published-print":{"date-parts":[[2015,7,14]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.9829","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,8]]},"published":{"date-parts":[[2015,6,3]]}}}