{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:38:03Z","timestamp":1783125483030,"version":"3.54.6"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Altered immune function after appendicectomy has been associated with autoimmune disease, even though the mechanisms are not clearly elucidated. This study aimed to investigate whether the frequency of new-onset type II diabetes was increased after appendicectomy in a case\u2013control study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective cohort study from the Taiwan Longitudinal Health Insurance Database 2000. The relative risk was compared with that in the general population using population-based data. Each patient was tracked for a 3-year interval to identify those who developed type II diabetes. Cox proportional hazard regression analysis was used to assess the risk of type II diabetes during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 31 512 patients were included in the study, of whom 5252 had an appendicectomy (study cohort) and 26 260 were matched for comparison. Some 714 patients (2\u00b73 per cent) developed type II diabetes during the 3-year follow-up, 161 in the study cohort (3\u00b71 per cent) and 553 in the comparison cohort (2\u00b71 per cent). The adjusted hazard ratio (HR) for type II diabetes in the study cohort was 1\u00b745 (95 per cent c.i. 1\u00b722 to 1\u00b774). This increased risk was most pronounced in men (adjusted HR 1\u00b747, 1\u00b716 to 1\u00b788) and in those with a perforated appendix (adjusted HR 2\u00b728, 1\u00b771 to 3\u00b703), and applied only to patients younger than 65 years of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An increased risk of new-onset type II diabetes within 3 years after appendicectomy was found in patients aged less than 65 years. The risk was highest in men and in those with complicated appendicitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9875","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T09:31:11Z","timestamp":1435570271000},"page":"1267-1271","source":"Crossref","is-referenced-by-count":8,"title":["Risk of new-onset type II diabetes after appendicectomy"],"prefix":"10.1093","volume":"102","author":[{"given":"P-L","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Cancer Centre, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-C","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Health Care 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