{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:07:21Z","timestamp":1791875241556,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":1988,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, but routine administration in surgery is not yet advocated owing to concerns regarding thromboembolic events. The aim of this study was to investigate whether topical application of tranexamic acid to a wound surface reduces postoperative bleeding.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a randomized double-blind placebo-controlled trial on 30 consecutive women undergoing bilateral reduction mammoplasty. On one side the wound surfaces were moistened with 25 mg\/ml tranexamic acid before closure, and placebo (saline) was used on the other side. Drain fluid production was measured for 24 h after surgery, and pain was measured after 3 and 24 h. Postoperative complications including infection, seroma, rebleeding and suture reactions were recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Topical application of tranexamic acid to the wound surface after reduction mammoplasty reduced drain fluid production by 39 per cent (median 12\u00b75 (range 0\u201344) versus 20\u00b75 (0\u2013100) ml; P = 0\u00b7038). Adverse effects were not observed. There were no significant differences in postoperative pain scores or complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Topical application of dilute tranexamic acid reduced bleeding in this model. The study adds to the evidence that this simple procedure may reduce wound bleeding after surgery. Registration number: NCT01964781 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.9878","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T15:00:16Z","timestamp":1441810816000},"page":"1348-1353","source":"Crossref","is-referenced-by-count":119,"title":["Randomized clinical trial of topical tranexamic acid after reduction mammoplasty"],"prefix":"10.1093","volume":"102","author":[{"given":"K","family":"Ausen","sequence":"first","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery, St Olav's University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Fossmark","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, St Olav's University Hospital, Trondheim, Norway"},{"name":"Departments of Cancer Research and Molecular Medicine, Children's and Women's Health, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Spigset","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacology, St Olav's University Hospital, Trondheim, Norway"},{"name":"Departments of Laboratory Medicine, Children's and Women's Health, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Pleym","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesia and Intensive Care, St Olav's University Hospital, Trondheim, Norway"},{"name":"Departments of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"2021021715531230800_bjs9878-bib-0001","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2165\/00003495-199957060-00017","article-title":"Tranexamic acid: a review of its use in surgery and other indications","volume":"57","author":"Dunn","year":"1999","journal-title":"Drugs"},{"key":"2021021715531230800_bjs9878-bib-0002","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/bjs.9193","article-title":"Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss","volume":"100","author":"Ker","year":"2013","journal-title":"Br J Surg"},{"key":"2021021715531230800_bjs9878-bib-0003","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e3054","article-title":"Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis","volume":"344","author":"Ker","year":"2012","journal-title":"BMJ"},{"key":"2021021715531230800_bjs9878-bib-0004","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.ejcts.2009.11.055","article-title":"Lessons from aprotinin: is the routine use and inconsistent dosing of tranexamic acid prudent? 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